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A new model is presented for assessing and evaluating the influence of bone-marrow-damaging substances in mice. Qualitative and quantitative results of histological, histochemical and enzyme histochemical studies facilitate the assessment of bone marrow damage in terms of extent and intensity. Bone marrow taken from the right femur of treated animals was embedded in renal tissue of controls for subsequent work-up in different techniques.
View Article and Find Full Text PDF[The preleukemic syndrome. Aspects of the problem and consideration of 5 cases].
Minerva Med
September 1980
Chronic acquired peripheral cytopenia, usually the result of ineffective myelopoiesis, is the main feature of the dysmyelopoiesis described as the preleukaemic syndrome. Probably attributable to a stem cell disorder, this condition may well progress to acute myeloblastic leukaemia. Five cases in which a retrospective diagnosis of preleukaemia was possible are presented.
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