AI Article Synopsis
- - Triciribine (TCN), a tricyclic nucleoside first synthesized in 1971, inhibits DNA synthesis and is particularly selective for the Akt pathway.
- - Although TCN showed limited single-agent effectiveness in solid tumors, it has demonstrated promising results when combined with various other treatments like dasatinib and gemcitabine against cancers like pancreatic and breast.
- - Beyond cancer treatment, TCN’s ability to inhibit Akt suggests potential benefits for treating lung injuries, including those caused by COVID-19.
Article Abstract
Triciribine (TCN) is a tricyclic nucleoside. Its synthesis was first described in 1971. Subsequent studies have indicated that TCN plays a role in inhibiting DNA synthesis and was revealed to possess a higher selectivity for Akt. Although a single dose of TCN demonstrated limited activity in solid tumors at the clinical level, combinations of TCN with various agents, such as specific inhibitors, tyrosine kinase inhibitor dasatinib, ErbB inhibitor tipifarnib, IGF1-R inhibitor NVP-AEW541, mTORC1 inhibitor RAD-001, TNF-related apoptosis-inducing ligand, PPARγ agonist, 1,25(OH)2D3, gemcitabine, and paclitaxel, have been reported to be efficient against various malignancies such as pancreatic, breast, prostate cancer, insulinoma, gut neuroendocrine tumor, and hepatocellular carcinoma at the preclinical level. Other than malignancies, through Akt inhibition activity, TCN has also been demonstrated potential for treating lung injuries, including those encountered in COVID-19 infections.
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| http://dx.doi.org/10.1080/1120009X.2024.2403050 | DOI Listing |
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