AI Article Synopsis
- * SOX9 is a key transcription factor that significantly influences sex determination and the development of male reproductive organs.
- * Recent research highlights the importance of gonadal enhancers in sex determination, aiming to elucidate the regulatory mechanisms behind this process and aid in developing techniques for animal sex manipulation.
Article Abstract
The sex determination in mammals refers to the development of an initial bipotential organ, termed the bipotential gonad/genital ridge, into either a testis or an ovary at the early stages of embryonic development, under the precise regulation of transcription factors. SOX9 (SRY-box transcription factor 9) is a multifunctional transcription factor in mammalian development and plays a critical role in sex determination and subsequent male reproductive organs development. Recent studies have shown that several enhancers upstream of also play an important role in the process of sex determination. In this review, we summarize the progress on the role of and its gonadal enhancers in sex determination. This review will facilitate to understand the regulatory mechanism of sex determination of and provides a theoretical basis for the further development of animal sex manipulation technologies.
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| http://dx.doi.org/10.16288/j.yczz.24-146 | DOI Listing |
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