This paper addresses the challenge of trajectory planning for autonomous vehicles operating in complex, constrained environments. The proposed method enhances the hybrid A-star algorithm through back-end optimization. An adaptive node expansion strategy is introduced to handle varying environmental complexities. By integrating Dijkstra's shortest path search, the method improves direction selection and refines the estimated cost function. Utilizing the characteristics of hybrid A-star path planning, a quadratic programming approach with designed constraints smooths discrete path points. This results in a smoothed trajectory that supports speed planning using S-curve profiles. Both simulation and experimental results demonstrate that the improved hybrid A-star search significantly boosts efficiency. The trajectory shows continuous and smooth transitions in heading angle and speed, leading to notable improvements in trajectory planning efficiency and overall comfort for autonomous vehicles in challenging environments.
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http://dx.doi.org/10.3390/s24175746 | DOI Listing |
Alzheimers Dement
December 2024
Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
Background: Characterizing changes in cognitive function during the last years of life is vital for providing appropriate care, supporting quality of life, and planning for future demands on our medical and social resources. The aim of this project was to construct a cognitive function trajectory file spanning the last five years of life to better understand common patterns of cognitive aging.
Method: The analytic cohort included 2019 Medicare decedents, aged 50 or older at death, with five years of continuous enrollment before death (n = 1,952,408).
Alzheimers Dement
December 2024
Rutgers, The State University of New Jersey, Newark, NJ, USA.
Background: Most older adults prefer aging in place; however, patients with dementia and advanced illness often need institutional care, even if only for a brief period of time. In the context of the aging US population and the increasing number of individuals living with dementia, understanding place of care trajectory patterns is important for patient-centered care planning and health policy decisions. The purpose of this study was to characterize place of care trajectories during the last three years of life among Medicare beneficiaries diagnosed with dementia.
View Article and Find Full Text PDFBackground: Pivotal Alzheimer's Disease (AD) trials typically require thousands of participants, resulting in long enrollment timelines and substantial costs. We leverage deep learning predictive models to create prognostic scores (forecasted control outcome) of trial participants and in combination with a linear statistical model to increase statistical power in randomized clinical trials (RCT). This is a straightforward extension of the traditional RCT analysis, allowing for ease of use in any clinical program.
View Article and Find Full Text PDFBackground: Dementia, a growing health crisis, disproportionally affects persons from racial/ethnic backgrounds and individuals with comorbidities. Latelife change in cognition is complex and nonlinear, as well as differential for these individuals. These individuals are also largely underrepresented in clinical trials.
View Article and Find Full Text PDFBMC Palliat Care
January 2025
School of Medicine, University of Dundee, Dundee, UK.
Background: Discussing Advance Care Planning (ACP) with people living with dementia (PwD) is challenging due to topic sensitivity, fluctuating mental capacity and symptom of forgetfulness. Given communication difficulties, the preferences and expectations expressed in any ACP may reflect family and healthcare professional perspectives rather than the PwD. Starting discussions early in the disease trajectory may avoid this, but many PwD may not be ready at this point for such discussions.
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