AI Article Synopsis
- Vitamin D is important for immune health and might affect the risk of graft-versus-host disease (GvHD) in patients receiving hematopoietic stem cell transplants (HSCT).
- A review of studies found that HSCT patients often have low vitamin D levels (around 12.8 to 29.2 ng/mL) and that various supplementation methods exist, but results on vitamin D's impact on GvHD risk are mixed.
- While some studies link low vitamin D to a higher risk of acute GvHD, a clearer connection was found with chronic GvHD, indicating that further research is needed to assess vitamin D's potential therapeutic benefits in HSCT patients.
Article Abstract
Introduction/aim: Vitamin D plays a crucial role in immune modulation, which may influence the development of graft-versus-host disease (GvHD) in patients undergoing hematopoietic stem cell transplantation (HSCT). This study aims to evaluate the impact of vitamin D levels and supplementation on the incidence of GvHD in HSCT patients.
Methods: A narrative review was conducted across PubMed/Medline, Cochrane Library, CINAHL, and Embase databases.
Results: The reviewed studies indicated widespread vitamin D deficiency among HSCT patients, with baseline levels ranging from 12.8 to 29.2 ng/mL. Supplementation protocols varied significantly, with dosages ranging from 1000 IU/day to 60,000 IU/week. Post-supplementation levels improved in some studies. Studies exploring the relationship between vitamin D and GvHD showed mixed results. Lower baseline vitamin D levels were associated with an increased risk of acute GvHD in some studies, while others found no significant correlation. However, a significant association between low levels of vitamin D and the incidence of chronic GvHD was observed.
Conclusion: Vitamin D deficiency is prevalent in HSCT patients and may influence the risk of developing chronic GvHD. Future research should focus on larger and more rigorous studies to determine the optimal role of vitamin D as an adjuvant therapy in the context of HSCT.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11397640 | PMC |
| http://dx.doi.org/10.3390/nu16172976 | DOI Listing |
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