AI Article Synopsis
- Colorectal cancer (CRC) is a major global health concern and can be mitigated through early detection and dietary changes.
- The study focused on the role of polyamines, which are metabolites produced by gut microbiota and are important for gut health, in relation to colorectal lesions.
- Results indicated that specific dietary components and elevated levels of certain polyamines in feces may help predict the presence of colorectal lesions, highlighting -acetyl putrescine and cadaverine as potential diagnostic markers.
Article Abstract
Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. Early detection and the modification of risk factors, such as diet, can reduce its incidence. Among food components, polyamines are important for maintaining gastrointestinal health and are metabolites of gut microbiota. Their disruption is linked to CRC, making polyamines a potential marker of the disease. This study analyzed the relationship between dietary components, including polyamines, and the presence of polyamines in feces to determine whether their presence could contribute to predicting the occurrence of colorectal lesions in patients. In total, 59 participants of both sexes (aged 50 to 70 years) who had undergone colonoscopy screening for CRC (18 without and 41 with colorectal lesions) participated in the study. A nutritional survey and determination of fecal polyamine content were performed. Specific dietary components and putrescine levels were higher in patients with colorectal lesions. The diet ratio of putrescine-spermidine and the fecal content of -acetyl putrescine and cadaverine were elevated in patients with precancerous lesions and adenocarcinomas, showing a potential predictive value for the presence of colorectal lesions. These findings suggest that -acetyl putrescine and cadaverine could be complementary markers for the diagnosis of suspected colorectal lesions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11397480 | PMC |
| http://dx.doi.org/10.3390/nu16172894 | DOI Listing |
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