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Genetic intratumour heterogeneity and clonal evolution in extramammary Paget's disease.
Eur J Dermatol
April 2024
Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan.
All tumour cells in a patient have shared and non-shared genetic alterations, and the diversity of mutations is described as intratumoural heterogeneity (ITH). Multiregion sequencing is a genome sequencing analytical technique used for multiple, spatially-separated biopsy tissues that may further our understanding of ITH and tumour evolution. Although genetic mutations in extramammary Paget's disease (EMPD) have recently been detected by next-generation sequencing analysis, there have been no reports of ITH based on multiregion sequencing in EMPD.
View Article and Find Full Text PDFHeadache and Status Epilepticus Reveal Paget's Disease of the Bone.
Cureus
May 2024
Department of Neurology B and Neurogenetics, Specialties Hospital, Ibn Sina Teaching Hospital, Mohammed V University in Rabat, Rabat, MAR.
Paget's disease of the bone (PDB) is a benign osteodystrophy of the elderly characterized by excessive remodeling of bone tissue, mainly in the pelvis, femur, and skull. Its neurological manifestations are numerous and affect both the central and peripheral nervous systems. As headaches are often reported, epileptic seizures remain exceptional.
View Article and Find Full Text PDFThe evolution of poller screws.
EFORT Open Rev
April 2024
Department of Trauma and Orthopaedics, Addenbrookes Major Trauma Unit, Cambridge University Hospitals, United Kingdom.
Compared to other techniques, poller screws with intramedullary nailing are technically simple, practical, and reproducible for the fixation of metaphyseal fractures. In addition, poller screws do not require special instruments or hardware and are minimally invasive. This review takes a historical perspective to evaluate poller screws holistically.
View Article and Find Full Text PDFReview of Classification Systems for Adult Acquired Flatfoot Deformity/Progressive Collapsing Foot Deformity and the Novel Development of the Triple Classification Delinking Instability/Deformity/Reactivity and Foot Type.
J Clin Med
February 2024
James Paget University Hospitals, NHS Foundation Trust, Great Yarmouth NR31 6LA, UK.
Classifications of AAFD/PCFD have evolved with an increased understanding of the pathology involved. A review of classification systems helps identify deficiencies and respective contributions to the evolution in understanding the classification of AAFD/PCFD. Using multiple electronic database searches (Medline, PubMed) and Google search, original papers classifying AAFD/PCFD were identified.
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