: To compare the prevalence of intra-ocular inflammation (IOI) between brolucizumab and aflibercept in neovascular age-related macular degeneration (nAMD) after intra-vitreal injections (IVI) and to compare the IOI odds ratios (ORs) of both therapies with the prevalence of septic endophthalmitis after IVI that was previously reported in the literature. : A total of 468 IVI of brolucizumab (117 eyes) were compared with 2884 IVI of aflibercept (305 eyes) regarding IOI and occlusive retinal vasculitis (RV) from December 2021 to June 2023 in this retrospective study. The OR was calculated for both anti-VEGF agents and was compared with the relative risk of septic endophthalmitis after IVI. : There were four eyes with unilateral IOI related to brolucizumab (3.42%), one presenting uveitis (0.85%), two vitritis (1.71%) and the last one presenting occlusive RV (0.85%), compared with two eyes presenting unilateral IOI (anterior uveitis, 0.66%) and none with RV from the aflibercept cohort. The incidence of IOI per injection with brolucizumab (0.855%) was significantly higher compared with aflibercept (0.069%, = 0.004). The OR of IOI related to brolucizumab IVI compared with septic endophthalmitis was 20 times greater (1.49 for aflibercept, = 0.646, versus 20.15 for brolucizumab, < 0.001). The OR of RV with brolucizumab compared with septic endophthalmitis was 4.6. : Data from our department suggest a much higher risk of IOI and occlusive retinal vasculitis after brolucizumab when compared with aflibercept. The risk of IOI and severe sight-threatening complications related to brolucizumab is greater than the risk of septic endophthalmitis after any IVI.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11396242 | PMC |
| http://dx.doi.org/10.3390/jcm13175208 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Unique Case of Hypervirulent Invasive Syndrome with Endogenous Endophthalmitis and Left Renal Vein Thrombosis without Liver Abscess.
Eur J Case Rep Intern Med
October 2024
Internal Medicine Department, Rashid Hospital, Dubai Health, Dubai, United Arab Emirates.
Article Synopsis
- This case report discusses a rare presentation of hypervirulent invasive syndrome (KPIS) in a 54-year-old woman without the typical liver abscesses associated with the condition.
- The patient exhibited multiple severe symptoms, including abdominal pain and signs of septic shock, along with complications like acute pyelonephritis and potential vision-threatening endophthalmitis.
- The report emphasizes the need for prompt interdisciplinary care and the importance of recognizing atypical manifestations of KPIS, particularly in cases affecting multiple organ systems.
Inflammation and Vasculitis Related to Brolucizumab.
J Clin Med
September 2024
Ophtalmology Department, Centro Hospitalar de Leiria, 2410-197 Leiria, Portugal.
: To compare the prevalence of intra-ocular inflammation (IOI) between brolucizumab and aflibercept in neovascular age-related macular degeneration (nAMD) after intra-vitreal injections (IVI) and to compare the IOI odds ratios (ORs) of both therapies with the prevalence of septic endophthalmitis after IVI that was previously reported in the literature. : A total of 468 IVI of brolucizumab (117 eyes) were compared with 2884 IVI of aflibercept (305 eyes) regarding IOI and occlusive retinal vasculitis (RV) from December 2021 to June 2023 in this retrospective study. The OR was calculated for both anti-VEGF agents and was compared with the relative risk of septic endophthalmitis after IVI.
View Article and Find Full Text PDFEndogenous endophthalmitis secondary to Lemierre's Syndrome originating from pharyngotonsillitis.
J Ophthalmic Inflamm Infect
August 2024
Hospital Universitario de Navarra, Pamplona, Spain.
Article Synopsis
- This article discusses a case of Lemierre's Syndrome leading to serious eye complications in a healthy 17-year-old woman with tonsillitis.
- After experiencing fever and pneumonia, she was admitted to the ICU where her eye problems were identified as endogenous endophthalmitis due to septic emboli.
- The article emphasizes the importance of conducting eye assessments for all patients with Lemierre's Syndrome, even if they don’t show initial eye symptoms, as part of comprehensive care.
A Retrospective Review of Endogenous Endophthalmitis: Three Years of Experience at Sultan Ahmad Shah Medical Centre at International Islamic University Malaysia.
Cureus
June 2024
Ophthalmology, Kulliyyah of Medicine, International Islamic University Malaysia, Kuantan, MYS.
Introduction Endogenous endophthalmitis is characterized by severe intraocular inflammation caused by the invasion of microorganisms into the anterior and posterior chambers of the eye. It results from hematogenous spread from distant foci of infection. This, in turn, leads to potential vision loss and blindness due to reduced anatomical and functional outcomes.
View Article and Find Full Text PDFPovidone-iodine in vitro antiseptic efficacy as a function of exposure duration, concentration, preparation, and length of storage.
Graefes Arch Clin Exp Ophthalmol
December 2024
Flaum Eye Institute, University of Rochester Medical Center, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA.
Purpose: Although 5% povidone-iodine (PVP-I) is frequently used as an ocular antiseptic agent, there is a lack of consensus regarding the effects of PVP-I concentration, storage after opening, and compounded preparation on PVP-I antisepsis. We performed a series of in-vitro experiments to determine the impact of these factors on PVP-I's inhibition of common causes of post-procedural eye infection.
Methods: Inhibition of microorganism growth was measured in-vitro as a function of active PVP-I exposure time.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!