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Efficient Solution-Phase Dipeptide Synthesis Using Titanium Tetrachloride and Microwave Heating. | LitMetric

Efficient Solution-Phase Dipeptide Synthesis Using Titanium Tetrachloride and Microwave Heating.

Int J Mol Sci

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Arcavacata di Rende, Italy.

Published: September 2024

AI Article Synopsis

Article Abstract

Microwaves have been successfully employed in the Lewis acid titanium tetrachloride-assisted synthesis of peptide systems. Dipeptide systems with their amino function differently protected with urethane protecting groups have been synthesized in short periods of time and with high yields. The formation of the peptide bond between the two reacting amino acids was achieved in pyridine by using titanium tetrachloride as a condensing agent and heating the reaction mixture with a microwave reactor. The reaction conditions are compatible with amino acids featuring various side chains and different protecting groups on both the amino function and side chains. Additionally, the substrates retain their chiral integrity after reaction.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11395851PMC
http://dx.doi.org/10.3390/ijms25179729DOI Listing

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