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Study of Pentacyclic Triterpenes from Lyophilised Aguaje: Anti-Inflammatory and Antioxidant Properties. | LitMetric

AI Article Synopsis

  • The Aguaje or Moriche palm is valued in South America for its medicinal properties, particularly its anti-inflammatory and antioxidant effects, but the specific bioactive compounds responsible have not been well studied.
  • This research successfully isolated three pentacyclic triterpenoid compounds using techniques like Nuclear Magnetic Resonance and Mass Spectrometry, with one compound showing significant inhibitory effects on inflammation-related processes.
  • The study highlights the potential of these compounds, especially one that activates key antioxidant enzymes, suggesting they may lead to safer and more effective treatments for diseases related to inflammation and oxidative stress.

Article Abstract

, commonly known as Aguaje or Moriche palm, is traditionally recognised in South America for its medicinal properties, particularly for its anti-inflammatory and antioxidant effects. However, the bioactive compounds responsible for these effects have not been thoroughly investigated. This study aims to isolate and characterise pentacyclic triterpenoid compounds from and to evaluate their therapeutic potential. Using various chromatographic and spectroscopic techniques including Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS), three pentacyclic triterpenoid compounds were successfully isolated. Among them, compound (3,11-dioxours-12-en-28-oic acid) exhibited notable bioactivity, significantly inhibiting the activation of Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) (IC = 7.39-8.11 μM) and of Nitric Oxide (NO) (IC = 4.75-6.59 μM), both of which are key processes in inflammation. Additionally, compound demonstrated potent antioxidant properties by activating the antioxidant enzyme Superoxide Dismutase (SOD) (EC = 1.87 μM) and the transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) (EC = 243-547.59 nM), thus showing its potential in combating oxidative stress. This study is the first to isolate and characterise the three compounds from , suggesting that compound could be a promising candidate for the development of safer and more effective therapies for inflammatory and oxidative stress-related diseases.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11395096PMC
http://dx.doi.org/10.3390/ijms25179615DOI Listing

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