AI Article Synopsis
- Communication between NK cells and monocytes/macrophages is crucial for regulating the immune response and inflammation.*
- The study focused on how NK cell-derived large extracellular vesicles (LEVs) affect the characteristics of THP-1 cells, a type of monocyte, by observing changes in their phenotype and functions.*
- Findings reveal that these LEVs can integrate into THP-1 cell membranes and significantly influence their viability and immune functions, highlighting their role in NK cell immunomodulation.*
Article Abstract
Communication between natural killer cells (NK cells) and monocytes/macrophages may play an important role in immunomodulation and regulation of inflammatory processes. The aim of this research was to investigate the impact of NK cell-derived large extracellular vesicles on monocyte function because this field is understudied. We studied how NK-cell derived large extracellular vesicles impact on THP-1 cells characteristics after coculturing: phenotype, functions were observed with flow cytometry. In this study, we demonstrated the ability of large extracellular vesicles produced by NK cells to integrate into the membranes of THP-1 cells and influence the viability, phenotype, and functional characteristics of the cells. The results obtained demonstrate the ability of large extracellular vesicles to act as an additional component in the immunomodulatory activity of NK cells in relation to monocytes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11395174 | PMC |
| http://dx.doi.org/10.3390/ijms25179478 | DOI Listing |
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