AI Article Synopsis
- Chitosan-based biomaterials are being studied for their ability to enhance skin regeneration and heal wounds.
- The focus of the study was on a mupirocin-loaded PEGylated chitosan nanoparticulate film (CBNF), which was characterized using FTIR spectroscopy and SEM analysis, confirming successful incorporation and small nanoparticle size.
- The CBNF demonstrated high water absorption, moderate water retention, and significant healing efficacy shown by improved tissue development after 19 days, highlighting its potential use as a drug delivery system for anti-inflammatory medications.
Article Abstract
Chitosan-based biomaterials are being investigated for their unique properties that support skin regeneration and wound healing. This study focused on the preparation and characterization of a mupirocin (Mup)-loaded PEGylated chitosan (CS-PEG) nanoparticulate film (NF) [CBNF]. The CBNF was characterized using FTIR spectroscopy and SEM analysis. The results demonstrated that CBNF was successfully incorporated into the composites, as shown by functional group modification through FTIR analysis. Additionally, the SEM micrograph revealed the deposition of nanoparticles (<200 nm) on the surface of transparent CBNF. The film has higher water absorption (≥1700%) and moderate water retention ability within 6 h. Furthermore, histological findings showed significant development, with re-epithelialization and granulation of tissues after 19 days, indicating the healing efficiency of CNBF. These results suggest that drug-loaded films could be an effective carrier and delivery agent for Mup-like anti-inflammatory drugs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11394824 | PMC |
| http://dx.doi.org/10.3390/ijms25179188 | DOI Listing |
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Article Synopsis
- Chitosan-based biomaterials are being studied for their ability to enhance skin regeneration and heal wounds.
- The focus of the study was on a mupirocin-loaded PEGylated chitosan nanoparticulate film (CBNF), which was characterized using FTIR spectroscopy and SEM analysis, confirming successful incorporation and small nanoparticle size.
- The CBNF demonstrated high water absorption, moderate water retention, and significant healing efficacy shown by improved tissue development after 19 days, highlighting its potential use as a drug delivery system for anti-inflammatory medications.
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