Human Endometrial Pericytes: A Comprehensive Overview of Their Physiological Functions and Implications in Uterine Disorders.

Cells

WHO Collaborating Centre, Division of Neonatology, Obstetrics, Gynecology, and Reproductive Health, Department of Women's and Children's Health, Karolinska University Hospital, Karolinska Institutet, SE 17176 Stockholm, Sweden.

Published: September 2024

Pericytes are versatile cells integral to the blood vessel walls of the microcirculation, where they exhibit specific stem cell traits. They are essential in modulating blood flow, ensuring vascular permeability, and maintaining homeostasis and are involved in the tissue repair process. The human endometrium is a unique and complex tissue that serves as a natural scar-free healing model with its cyclical repair and regeneration process every month. The regulation of pericytes has gained increasing attention due to their involvement in various physiological and pathological processes. However, endometrial pericytes are less well studied compared to the pericytes in other organs. This review aims to provide a comprehensive overview of endometrial pericytes, with a focus on elucidating their physiological function and potential implications in uterine disorders.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11394273PMC
http://dx.doi.org/10.3390/cells13171510DOI Listing

Publication Analysis

Top Keywords

endometrial pericytes
12
comprehensive overview
8
implications uterine
8
uterine disorders
8
pericytes
6
human endometrial
4
pericytes comprehensive
4
overview physiological
4
physiological functions
4
functions implications
4

Similar Publications

Characterization and angiogenic potential of CD146 endometrial stem cells.

Stem Cell Res Ther

September 2024

Department of Stem Cells & Regenerative Medicine, D.Y. Patil Education Society (Deemed to be University), D. Y. Patil Vidyanagar, Kasab Bawada, Kolhapur, 416006, Maharashtra, India.

Article Synopsis
  • - The study investigates the role of endometrial stem cells (eSCs) in tissue regeneration and angiogenesis, particularly focusing on CD146 as a key marker that enhances the regenerative and vascular growth potential of these cells.
  • - Researchers isolated eSCs from biopsies of active reproducing women and conducted various analyses to assess their properties, including growth factor secretion and angiogenic capabilities, using functional assays.
  • - The findings potentially pave the way for innovative eSC-based therapies in regenerative medicine and the treatment of vascular disorders by understanding CD146's influence on eSCs' angiogenic functions.
View Article and Find Full Text PDF

Human Endometrial Pericytes: A Comprehensive Overview of Their Physiological Functions and Implications in Uterine Disorders.

Cells

September 2024

WHO Collaborating Centre, Division of Neonatology, Obstetrics, Gynecology, and Reproductive Health, Department of Women's and Children's Health, Karolinska University Hospital, Karolinska Institutet, SE 17176 Stockholm, Sweden.

Pericytes are versatile cells integral to the blood vessel walls of the microcirculation, where they exhibit specific stem cell traits. They are essential in modulating blood flow, ensuring vascular permeability, and maintaining homeostasis and are involved in the tissue repair process. The human endometrium is a unique and complex tissue that serves as a natural scar-free healing model with its cyclical repair and regeneration process every month.

View Article and Find Full Text PDF

Pericytes (PCs) are versatile cells integral to the microcirculation wall, exhibiting specific stem cell traits. They are essential in modulating blood flow, ensuring vascular permeability, maintaining homeostasis, and aiding tissue repair process. Given their involvement in numerous disease-related pathological and physiological processes, the regulation of PCs has emerged as a focal point of research.

View Article and Find Full Text PDF

Estrogen and progesterone, acting through their cognate receptors the estrogen receptor α (ERα) and the progesterone receptor (PR) respectively, regulate uterine biology. Using rapid immunoprecipitation and mass spectrometry (RIME) and co-immunoprecipitation, we identified TRIM28 (Tripartite motif containing 28) as a protein which complexes with ERα and PR in the regulation of uterine function. Impairment of TRIM28 expression results in the inability of the uterus to support early pregnancy through altered PR and ERα action in the uterine epithelium and stroma by suppressing PR and ERα chromatin binding.

View Article and Find Full Text PDF

Resveratrol alleviates doxorubicin-induced damage in mice ovary.

Chem Biol Interact

May 2023

Instituto de Biología y Medicina Experimental (IByME) - CONICET, Buenos Aires, Argentina. Electronic address:

While oocytes and embryos cryopreservation can favor some patients with cancer-induced infertility to achieve pregnancy, the development of effective therapeutic strategies to preserve ovarian function during chemotherapy would be a significant advantage. The aim of the present study is to analyze whether Resveratrol treatment (Res) can preserve ovarian function from doxorubicin (Doxo)-induced gonadotoxicity using a mice model of premature ovarian failure. Res (7 and 15 mg/kg) increased the percentage of primary and antral follicles whilst decreasing the percentage of atretic follicles compared to Doxo alone.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!