AI Article Synopsis
- Pituitary adenomas are benign tumors that make up about 18% of intracranial tumors and often require surgery, where distinguishing between healthy pituitary tissue and adenoma is critical to avoid complications.
- A study involving 34 patients with non-functional macroadenomas tested the effectiveness of ICG dye during surgery, comparing outcomes with a control group; hormone functions were assessed pre and postoperatively.
- Results showed that postoperative diabetes insipidus occurred in 5.9% of the ICG group versus 23.5% in the control group, but overall adenohypophysis function worsened in a higher percentage of the ICG group, leading to the conclusion that the dye's benefits remain unproven and
Article Abstract
(1) Background: Pituitary adenomas are benign tumors comprising about 18% of all intracranial tumors, and they often require surgical intervention. Differentiating pituitary tissue from adenoma during surgery is crucial to minimize complications. We hypothesized that using ICG dye would reduce the hormonal complication rates. (2) Methods: A prospective randomized study (February 2019-October 2023) included 34 patients with non-functional macroadenomas of the pituitary gland randomly assigned to receive intraoperative ICG or be in the control group. All underwent endoscopic endonasal transsphenoidal surgery. Pituitary function was assessed preoperatively, immediately postoperatively, and 3-6 months postoperatively. Adenohypophysis function was evaluated with hormonal tests (Cosyntropin stimulation test, TSH, fT3, fT4, prolactin, IGF-1, FSH, LH, and testosterone in men) and neurohypophysis function with fluid balance, plasma and urine osmolality, and serum and urinary sodium. (3) Results: Of the 34 patients (23 men, 11 women; average age 60.9 years), 5.9% in the ICG group developed diabetes insipidus postoperatively, compared to 23.5% in the control group. Adenohypophysis function worsened in 52.9% of the ICG group and in 35.3% of the control group. (4) Conclusions: Our study did not confirm the benefits of using ICG in these surgeries. Further research with a larger sample is needed.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11393862 | PMC |
| http://dx.doi.org/10.3390/diagnostics14171863 | DOI Listing |
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