AI Article Synopsis
- Cancer is the leading cause of death in adult dogs, with a significant chance (one-third) of developing it during their lifetime.
- A study using shallow whole-genome sequencing analyzed blood cell-free DNA from four dogs with tumors (one benign and three malignant) and 38 healthy dogs.
- Results showed that healthy dogs and the benign tumor dog had no copy number aberrations, while the malignant tumor dogs exhibited noticeable copy number variations and shorter DNA fragment sizes, indicating the potential for non-invasive cancer detection in dogs.
Article Abstract
Objective: Cancer is currently the most common cause of death in adult dogs. Like humans, dogs have a one-third chance of developing cancer in their lifetime. We used shallow whole-genome sequencing (sWGS) to analyze blood cell-free DNA (cfDNA) from four tumor-bearing dogs (one with benign and three with malignant tumors) and 38 healthy dogs.
Results: Similar to the results observed in the healthy dogs, no copy number aberration (CNA) was detected in the dog with benign lipomas, and the distribution of cfDNA fragment size (FS) closely resembled that of the healthy dogs. However, among the three dogs diagnosed with malignant tumors, two dogs exhibited varying degrees and quantities of CNAs. Compared to the distribution of FS in the healthy dogs, the cancer dogs exhibited a noticeable shift towards shorter lengths. These findings indicated that CNA and FS profiles derived from sWGS data can be used for non-invasive cancer detection in dogs.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11401444 | PMC |
| http://dx.doi.org/10.1186/s13104-024-06932-3 | DOI Listing |
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