AI Article Synopsis

  • Aframomum melegueta, or grains of paradise, is a medicinal plant known for its beneficial phytochemicals and healing properties, which were evaluated for antioxidant and cytotoxic effects using both in vitro and in vivo methods.
  • Key compounds found in the extracts included gallic acid, caffeic acid, and quercetin, and the extracts showed significant antioxidant activity while being safe for animal health based on chronic toxicity tests.
  • The study indicates the extracts' potential in preventing oxidative stress-related diseases by protecting cells from damage and improving overall health.

Article Abstract

Aframomum melegueta, commonly known as grains of paradise, is a medicinal plant celebrated for its rich phytochemical content and therapeutic properties. This study evaluated the antioxidant and cytotoxic potentials of its ethanolic and methanolic extracts, both in vitro and in vivo, while also analyzing their chemical profiles. HPLC analysis identified key compounds, including gallic acid, caffeic acid, caffeine, coumarin, rutin, catechin, ferulic acid, and quercetin. Chronic toxicity assessments confirmed the safety of the extracts, with no adverse effects on animal health, particularly in liver histopathology. Cytotoxicity results indicated reduced splenocyte viability at the highest concentrations. The extracts exhibited significant antioxidant activity in DPPH, FRP, and phosphomolybdate assays, demonstrating their effectiveness as antiradical agents. In vivo antioxidant results showed a reduction in lipid peroxidation levels in serum and liver, highlighting the extracts' ability to mitigate oxidative stress. Additionally, the extracts provided protection against HO-induced erythrocyte hemolysis and modulated NO production in peritoneal macrophages. These findings underscore the therapeutic potential of A. melegueta extracts, suggesting their promise in developing preventive strategies for oxidative stress-related chronic diseases.

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http://dx.doi.org/10.1002/cbdv.202400942DOI Listing

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Article Synopsis
  • Aframomum melegueta, or grains of paradise, is a medicinal plant known for its beneficial phytochemicals and healing properties, which were evaluated for antioxidant and cytotoxic effects using both in vitro and in vivo methods.
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  • The study indicates the extracts' potential in preventing oxidative stress-related diseases by protecting cells from damage and improving overall health.
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