AI Article Synopsis
- IL-17 family cytokines are important for causing inflammation and play a key role in various skin disorders, including autoimmune diseases.
- While IL-17A has been well-studied and led to effective treatments for psoriasis, other IL-17 family members are less understood.
- This review discusses recent advancements in the knowledge of IL-17 cytokines, their sources, receptors, and pathways, and how their dysfunction can lead to skin diseases.
Article Abstract
As potent pro-inflammatory mediators, IL-17 family cytokines play crucial roles in the pathogenesis of various inflammatory and autoimmune skin disorders. Although substantial progress has been achieved in understanding the pivotal role of IL-17A signaling in psoriasis, leading to the development of highly effective biologics, the functions of other IL-17 family members in inflammatory or autoimmune skin diseases remain less explored. In this review, we provide a comprehensive overview of IL-17 family cytokines and their receptors, with a particular focus on the recent advancements in identifying cellular sources, receptors and signaling pathways regulated by these cytokines. At the end, we discuss how the aberrant functions of IL-17 family cytokines contribute to the pathogenesis of diverse inflammatory or autoimmune skin diseases.
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| http://dx.doi.org/10.1016/bs.ai.2024.07.002 | DOI Listing |
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