AI Article Synopsis
- - The study aimed to explore how genetic risk, healthy lifestyle habits, and susceptibility to hyperuricaemia (high uric acid levels) are interconnected in a group of over 7,200 participants aged 20 and above.
- - Results showed that 3% of participants developed hyperuricaemia over 3.5 years, with those having both high genetic risk and poor lifestyle choices significantly more likely to develop the condition (odds ratio: 5.34).
- - The findings suggest that maintaining a healthy lifestyle can lower the risk of hyperuricaemia despite genetic predispositions, indicating that both genetic and lifestyle factors are important for identifying individuals at risk.
Article Abstract
Objective: To investigate the inter-relationships among genetic risk, healthy lifestyle adherence, and hyperuricaemia susceptibility.
Methods: This prospective cohort study was conducted with 7,241 hyperuricaemia-free individuals aged ≥ 20 years from the Tohoku Medical Megabank Community-based cohort study. A comprehensive lifestyle score included body mass index, smoking, drinking, and physical activity, and a polygenic risk score (PRS) was constructed based on uric acid loci from a previous genome-wide association study meta-analysis. A multiple logistic regression model was used to estimate the association between genetic risk, healthy lifestyle, and hyperuricaemia incidence and calculate the area under the receiver operating characteristic curve (AUROC). Hyperuricaemia was defined as a uric acid level ≥7.0 mg/dl or a self-reported history of hyperuricaemia.
Results: Of the 7,241 adults (80.7% females; mean [SD] age: 57.7 [12.6] years), 217 (3.0%) developed hyperuricaemia during 3.5 years of follow-up. Genetic risk correlated with hyperuricaemia development (P for interaction = 0.287), and lifestyle risks were independently associated. Those with a high genetic risk and poor lifestyle had the highest risk (odds ratio: 5.34; 95% confidence interval [CI]: 2.61-12.10). Although not statistically significant, incorporating the PRS in the model with lifestyle information improved predictive ability (AUROC = 0.771, 95% CI: 0.736-0.806 for lifestyle; AUROC = 0.785, 95% CI: 0.751-0.819 for lifestyle and PRS; p = 0.07).
Conclusion: : A healthy lifestyle to prevent hyperuricaemia, irrespective of genetic risk, may mitigate the genetic risk. Genetic risk may complement lifestyle factors in identifying individuals at a heightened hyperuricaemia risk.
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Source |
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| http://dx.doi.org/10.1093/rheumatology/keae492 | DOI Listing |
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