AI Article Synopsis
- Adult-onset Still's disease (AOSD) is a rare inflammatory disorder marked by symptoms like fevers, skin rashes, arthritis, and high ferritin levels, but its cause is unknown.
- Detecting AOSD early is challenging due to its nonspecific symptoms and lack of biomarkers, making diagnosis difficult.
- A study involving musculoskeletal ultrasound (MSKUS) on 11 patients revealed various inflammatory conditions such as tenosynovitis and bursitis, highlighting the diverse joint-related manifestations of AOSD.
Article Abstract
Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology characterized by high spiking fever, salmon-like skin rash, arthritis, and elevated serum ferritin levels. Early detection of AOSD is remarkably difficult because of the lack of serologic biomarkers, nonspecific presentation, and rarity of the disease. Although arthralgia and arthritis are the most frequent symptoms and are correlated with health-related quality of life in patients with AOSD, the inflammatory changes associated with these symptoms have not been elucidated. We performed musculoskeletal ultrasound (MSKUS) in 11 patients between January 1, 2008 and July 31, 2023, seven of whom had abnormalities. MSKUS findings of those cases suggested that some patients with AOSD could present with tenosynovitis, tendonitis/peritendonitis, bursitis, and enthesitis along with synovitis. This case series demonstrate the diversity of inflammatory articular manifestations of AOSD identified by MSKUS.
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| http://dx.doi.org/10.1016/j.jbspin.2024.105771 | DOI Listing |
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