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Molecular characterization of archival adrenal tumor tissue from patients with ACTH-independent Cushing syndrome.
J Steroid Biochem Mol Biol
December 2024
Department of Pathology, University of Michigan, Ann Arbor, MI, United States; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, United States; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, United States.
Cushing syndrome represents a multitude of signs and symptoms associated with long-term and excessive exposure to glucocorticoids. Solitary cortisol-producing adenomas (CPAs) account for most cases of ACTH-independent Cushing syndrome (CS). Technological advances in next-generation sequencing have significantly increased our understanding about the genetic landscape of CPAs.
View Article and Find Full Text PDFLarger size of Conn's adenoma is associated with lower cure rates post adrenalectomy.
Langenbecks Arch Surg
November 2024
Division of Endocrine Surgery, National University Hospital, Singapore, Singapore.
Background: The cure for patients with primary hyperaldosteronism (PHA) secondary to solitary adrenal adenoma is adrenalectomy. We investigated the impact of size of Conns' tumour on hypertension resolution in a multi-ethnic South East Asian Cohort.
Methods: Retrospective cohort study of patients who underwent surgery for PHA between January 2010 to December 2022 was performed.
Unilateral adrenal metastases as an unusual primary presentation of hepatocellular carcinoma: a case report and literature review.
Ann Med Surg (Lond)
November 2024
Spinghar Medical University, Kabul, Afghanistan.
Introduction And Importance: Adrenal metastases can rarely present as a solitary clinical manifestation among cases with underlying hepatocellular carcinoma (HCC).
Case Presentation: The authors present the case of a 53-year-old male with chronic liver disease due to chronic hepatitis C who presented with left flank pain. Imaging revealed a left-sided suprarenal mass.
Primary and "Pre-Primary" Aldosteronism in Resistant Hypertension: A Practical, Pragmatic, and Prudent Approach in Resource-Limited Milieu.
Cureus
October 2024
Endocrinology, Diabetes and Metabolism, Samatvam Endocrinology Diabetes Center, Samatvam: Science and Research for Human Welfare Trust, Bangalore, IND.
Introduction Primary aldosteronism (PA), once considered rare, is now recognized as the most common cause of secondary hypertension, accounting for almost a quarter of resistant hypertension (RH) cases. Despite this, PA remains underdiagnosed, with an extremely low percentage of RH patients undergoing screening. Methods In a specialty diabetes-endocrinology clinic, the aldosterone:renin ratio (ARR) was assessed in 115 consecutive RH patients (ages 21-93 years; 47% male; 87% with type 2 diabetes).
View Article and Find Full Text PDFSolitary adrenal metastasis of breast cancer on [Ga]Ga-DOTA-TATE PET/CT.
Rev Esp Med Nucl Imagen Mol (Engl Ed)
September 2024
Department of Nuclear Medicine, Marmara University Pendik Training and Research Hospital, Istanbul, Turkey.
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