A variety of analgesic drugs were tested for their ability to alter the response to noxious stimuli of differing severity in an attempt to develop a procedure to evaluate differences in efficacy of different analgesics. The severity of a noxious stimuli delivered to mice was varied by immersing the mouse tails in water maintained at 45, 50, 55 degrees C. As has been previously observed, the opiate analgesics morphine and nalorphine were active at all temperatures. Pentazocine was active at 45 and 50 degrees C, but not at 55 degrees C. The cyclooxygenase inhibitors tested showed a wide variety of activity. Naproxen was active at all temperatures. Zomepirac was active at 45 and 50 degrees C, but not 55 degrees C. Acetaminophen, ibuprofen, and fenoprofen were active at 45 degrees C, but not at higher temperatures. Aspirin and indomethacin were inactive at all temperatures tested. These results roughly paralleled the differences in the severity of pain for which these analgesics are effective.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0160-5402(85)90017-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of moisture in fire hoods and gloves on residual heat accumulation during repeated rest-work cycles at a fire scene.
Sci Prog
January 2025
National Fire Research Institute, Asan-si, Republic of Korea.
Firefighters are exposed to the risk of burns at fire scenes. In 2020, the National Fire Agency of the Republic of Korea surveyed 50,527 firefighters and identified 242 burn-related incidents. The body parts affected by these burns were the hands (28.
View Article and Find Full Text PDFSocial Network Analysis of Self-Management Behavior Among Older Adults With Diabetes.
Public Health Nurs
January 2025
College of Nursing, Chungnam National University, Daejeon, Republic of Korea.
Objective: This study explores the influence of social network structures on self-management behaviors among older adults with diabetes in rural Korean villages, focusing on dietary management, physical activity, and blood glucose monitoring.
Design: Employing social network analysis (SNA), the study assessed network structures in three villages, focusing on variations in degree, closeness, and betweenness centralities to understand their impact on health behavior dissemination and adoption.
Results: The analysis identified significant differences in network configurations across the villages.
Phosphorus-solubilizing fungi promote the growth of P. Y. Li by regulating physiological and biochemical reactions and protecting enzyme system-related gene expression.
Front Genet
January 2025
Chongqing Engineering Laboratory of Green Planting and Deep Processing of Famous-Region Drug in the Three Gorges Reservoir Region, College of Biology and Food Engineering, Chongqing Three Gorges University, Chongqing, China.
Introduction: P. Y. Li is a plant used to treat respiratory diseases such as pneumonia, bronchitis, and influenza.
View Article and Find Full Text PDFBurnout and its relationship with depressive symptoms in primary school teachers under the "Double Reduction" policy in China.
Front Public Health
January 2025
The Third People's Hospital of Ganzhou, Ganzhou, China.
Background: The "Double Reduction" policy requires schools to reduce Chinese students' extracurricular activities and homework to lessen academic stress and improve mental well-being. However, there is limited research on primary school teachers' psychological well-being within the context of the "Double Reduction" policy. This study examined self-reported burnout levels of primary school teachers and investigated the relationship between burnout and depressive symptoms in the context of the "Double Reduction" policy in China.
View Article and Find Full Text PDFSpatial and Temporal Relationships Between Roe and Red Deer in an Alpine Area.
Ecol Evol
January 2025
Stelvio National Park Bormio Italy.
Interspecific interactions are important drivers of population dynamics and species distribution. These relationships can increase niche partitioning between sympatric species, which can differentiate space and time use or modify their feeding strategies. Roe deer and red deer are two of the most widespread ungulate species in Europe and show spatial and dietary overlap.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!