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Effects of transurethral 0bipolar plasma prostatectomy on urodynamics and sexual function in patients with prostatic hyperplasia.
Afr J Reprod Health
December 2024
Department of Medical Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
This was an original article, and the objective of this study was to investigate the effects of bipolar transurethral plasma kinetic prostatectomy (TUPKP) on urodynamics and sexual function in benign prostatic hyperplasia (BPH) patients. One hundred and four BPH patients were divided into a control group and an intervention group. The control group received transurethral resection of prostate, while the intervention group received TUKEP.
View Article and Find Full Text PDFCombining radiotherapy with targeted therapy benefits patients with advanced epidermal growth factor receptor-mutated non-small cell lung cancer (EGFRm NSCLC). However, the optimal strategy to combine EGFR tyrosine kinase inhibitors (TKIs) with radiotherapy for maximum efficacy and minimal toxicity is still uncertain. Notably, EVs, which serve as communication mediators among tumor cells, play a crucial role in the anti-tumor immune response.
View Article and Find Full Text PDFUnveiling the Potential of C Factor Applied to Pilot Bioavailability/Bioequivalence Studies-A Case Study with Pazopanib Drug Products.
Pharmaceutics
December 2024
Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal.
When companies are uncertain about the potential of a new formulation to be bioequivalent to a Reference product, it is common practice to carry out downsized pilot studies as a gatekeeping in vivo strategy to decide whether to move forward or not with a full-size pivotal study. However, due to the small study size, these studies are inarguably more sensitive to variability. To address and mitigate the uncertainty of the conclusions of pilot studies concerning the maximum observed concentration (C), the factor was proposed as an alternative approach to the average bioequivalence statistical methodology.
View Article and Find Full Text PDFImproving the Impact Resistance and Post-Impact Tensile Fatigue Damage Tolerance of Carbon Fiber Reinforced Epoxy Composites by Embedding the Carbon Nanoparticles in Matrix.
Polymers (Basel)
December 2024
Department of Mechanical and Mechatronic Engineering, National Taiwan Ocean University, Keelung 202301, Taiwan.
The effect of dispersing multiwalled carbon nanotubes (MWCNTs) and graphene nanoplatelets (GNPs) in the matrix on the low-velocity impact resistance and post-impact residual tensile strength of the carbon fiber reinforced epoxy composite laminates has been experimentally analyzed in this study. The composite specimens with the matrix reinforced by different nanoparticle types and various nanoparticle concentrations (0.1, 0.
View Article and Find Full Text PDFFabrication and Performance Evaluation of a Novel Composite PVC-ZnO Membrane for Ciprofloxacin Removal by Polymer-Enhanced Ultrafiltration.
Polymers (Basel)
December 2024
Polymer Science Program, Division of Physical Science, Faculty of Science, Prince of Songkla University, Hat-Yai 90110, Thailand.
Water pollution is a major global issue, and antibiotic drugs released into aquatic environments by the pharmaceutical industry, such as ciprofloxacin, have negative consequences on both human health and the ecosystem. In this study, the performance of PVA as a polymer ligand for ciprofloxacin (CPFX) removal is evaluated through polymer-enhanced ultrafiltration using a novel composite PVC-ZnO membrane. The initial concentration of the ciprofloxacin solution, pH, ionic strength, ideal polymer concentration, duration, and maximum retention capacity were among the factors that were examined.
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