Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568448 | PMC |
| http://dx.doi.org/10.1164/rccm.202408-1513LE | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A double-edged sword role of IFN-γ-producing iNKT cells in sepsis: Persistent suppression of Treg cell formation in an Nr4a1-dependent manner.
iScience
December 2024
The Affiliated Zhongda Hospital, Clinical Medical College, Southeast University, Nanjing, Jiangsu, China.
Sepsis, a leading cause of mortality in intensive care units worldwide, lacks effective treatments for advanced-stage sepsis. Therefore, understanding the underlying mechanisms of this disease is crucial. This study reveals that invariant natural killer T (iNKT) cells have an opposing role in the progression of sepsis by suppressing regulatory T (Treg) cell differentiation and function.
View Article and Find Full Text PDFResearch on high-temperature fast pyrolysis of waste printed circuit boards for gas release and carbon structure evolution.
Waste Manag
December 2024
State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization, Kunming University of Science and Technology, Kunming 650093, China.
Pyrometallurgy has proven to be a highly effective method for the large-scale recycling of waste printed circuit boards (WPCB) in industrial settings. This study focused on the fast pyrolysis characteristics of WPCB at smelting temperatures and characterized the gas product release behavior and solid product features in detail. The results indicate that the pyrolysis gas was mainly composed of H, CH and CO, and the maximum yield of pyrolysis gas was obtained at 1300 °C, which was 233.
View Article and Find Full Text PDFMeasuring eating behavior and motivations in the United Arab Emirates and the United States: Evaluating measurement and predictive invariance of the Eating Disorder Examination Questionnaire-Short Form and the Eating Motivation Survey.
Psychol Assess
December 2024
Department of Psychology and Philosophy, Sam Houston State University.
Considerable proportions of college students in White, educated, industrialized, rich, and democratic countries, such as the United States, suffer from eating disorders and other problematic eating behaviors. The prevalence of eating disorders in Western Asia has been historically low but is rapidly increasing. One of the most dramatic increases is occurring in the United Arab Emirates.
View Article and Find Full Text PDFChemical, Biochemical, and Structural Similarities and Differences of Dermatological cAMP Phosphodiesterase-IV Inhibitors.
J Invest Dermatol
November 2024
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA; Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA; Program in Translational Biomedicine, Yale School of Medicine, New Haven, Connecticut, USA. Electronic address:
Article Synopsis
- - Roflumilast is the third PDE4 inhibitor used in dermatology for topical treatments of conditions like psoriasis and dermatitis, while earlier drugs like apremilast and crisaborole target oral and topical usage differently.
- - It is the most effective among the three inhibitors, showcasing a significantly lower IC value of 0.7 nM, compared to apremilast (0.14 μM) and crisaborole (0.24 μM), suggesting much greater potency.
- - The study highlights how PDE4 inhibitors improve anti-inflammatory responses by prolonging cAMP signals within immune cells, and discusses potential chemical modifications to enhance their effectiveness based on newly identified invariant residues and metal ion interactions in their catalytic domains
Control of hydrogen concentrations by microbial sulfate reduction in two contrasting anoxic coastal sediments.
Front Microbiol
November 2024
Department of Microbiology, The University of Tennessee, Knoxville, Knoxville, TN, United States.
Introduction: Molecular hydrogen is produced by the fermentation of organic matter and consumed by organisms including hydrogenotrophic methanogens and sulfate reducers in anoxic marine sediment. The thermodynamic feasibility of these metabolisms depends strongly on organic matter reactivity and hydrogen concentrations; low organic matter reactivity and high hydrogen concentrations can inhibit fermentation so when organic matter is poor, fermenters might form syntrophies with methanogens and/or sulfate reducers who alleviate thermodynamic stress by keeping hydrogen concentrations low and tightly controlled. However, it is unclear how these metabolisms effect porewater hydrogen concentrations in natural marine sediments of different organic matter reactivities.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!