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Peri-Implant Enhancement of the Breast: Imaging Features, Significance, and Management Strategies.
J Breast Imaging
December 2024
Division of Plastic and Reconstructive Surgery, Mayo Clinic in Florida, Jacksonville, FL, USA.
Objective: Peri-implant enhancement can be seen on contrast-enhanced breast MRI, but its association with malignancy has not been described, leading to considerable variability in assessment and recommendations by radiologists. This study evaluated imaging features, management, and outcomes of implant-related enhancement.
Methods: This multisite IRB-approved retrospective review queried all breast MRI reports for keywords describing peri-implant enhancement, fluid, and/or masses (plus synonymous descriptions) and implant-associated malignancies, with subsequent imaging and chart review.
The role of macrophages in liver fibrosis: composition, heterogeneity, and therapeutic strategies.
Front Immunol
December 2024
Department of Nuclear Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Article Synopsis
- Macrophages are key immune cells in the liver that help maintain liver health and respond to injuries caused by stressors, and they come in various types with different roles.
- The main types of liver macrophages include resident Kupffer cells, monocyte-derived macrophages from blood, lipid-associated macrophages near bile ducts, and liver capsular macrophages, each with specific functions.
- Recent research highlights the dual role of monocyte-derived macrophages in liver fibrosis: one subtype promotes fibrosis, while another aids in repairing and reducing it, showcasing the complexity of macrophage functions in liver health and disease.
Unraveling the Immune Web: Advances in SMI Capsular Fibrosis from Molecular Insights to Preclinical Breakthroughs.
Biomolecules
November 2024
Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Breast implant surgery has evolved significantly, yet challenges such as capsular contracture remain a persistent concern. This review presents an in-depth analysis of recent advancements in understanding the immune mechanisms and clinical implications associated with silicone mammary implants (SMIs). The article systematically examines the complex interplay between immune responses and capsular fibrosis, emphasizing the pathophysiological mechanisms of inflammation in the etiology of this fibrotic response.
View Article and Find Full Text PDFDevelopment of a fish oil-nanoemulsion gel as a drug-delivery system to prevent capsular contracture.
Sci Rep
November 2024
Department of Plastic and Reconstructive Surgery, Soonchunhyang University College of Medicine, Seoul, 04401, Republic of Korea.
Capsular contracture, a significant complication of breast-implant surgery, causes pain and deformation following the formation of a tight capsule around an implant. Current surgical and non-surgical treatment options are invasive, expensive, and typically administered for prolonged periods, potentially leading to side effects. To address these challenges, we developed a novel fish oil-encapsulated, poloxamer-based nanoemulsion gel with omega-3 (ω3) as the primary active component (NE-ω3 gel; N3G).
View Article and Find Full Text PDFSMI-Capsular Fibrosis and Biofilm Dynamics: Molecular Mechanisms, Clinical Implications, and Antimicrobial Approaches.
Int J Mol Sci
October 2024
Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Silicone mammary implants (SMIs) frequently result in capsular fibrosis, which is marked by the overproduction of fibrous tissue surrounding the implant. This review provides a detailed examination of the molecular and immunological mechanisms driving capsular fibrosis, focusing on the role of foreign body responses (FBRs) and microbial biofilm formation. We investigate how microbial adhesion to implant surfaces and biofilm development contribute to persistent inflammation and fibrotic responses.
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