AI Article Synopsis
- - Neoadjuvant therapy combining camrelizumab and chemotherapy shows promise for treating locally advanced esophageal squamous cell carcinoma (ESCC), but the best way to use it alongside chemotherapy is still unclear.
- - In a study with 55 patients, the treatment led to a major pathological response rate of 77.1%, and almost all patients had successful surgeries with significant rates of tumor downstaging.
- - The results indicated a 2-year disease-free survival (DFS) rate of 68.9% and an overall survival (OS) rate of 74.7%, while serious treatment-related side effects occurred in 12.7% of patients, suggesting the therapy was effective and generally safe.
Article Abstract
Background: Neoadjuvant therapy combining camrelizumab with chemotherapy has emerged as a promising approach for treating locally advanced esophageal squamous cell carcinoma (ESCC). However, the optimal strategy for integrating immunotherapy with chemotherapy remains to be fully defined. This single-arm phase II study aimed to evaluate the efficacy and safety of neoadjuvant therapy with camrelizumab induction followed by camrelizumab plus chemotherapy in locally advanced ESCC.
Methods: Patients with clinical stage cT2-4N0M0 or cTxN1-3M0 ESCC were enrolled in the study. Patients received one dose of camrelizumab (200 mg) followed by docetaxel (75 mg/m) and nedaplatin (75 mg/m) plus camrelizumab (200 mg) every 3 weeks for two cycles, and then underwent surgery within 3-4 weeks. The primary endpoint was the major pathological response (MPR) rate. The secondary endpoints included the pathological complete response (pCR) rate, R0 resection rate, downstaging rate, disease-free survival (DFS), overall survival (OS), and safety.
Results: In total, 55 patients were enrolled in the study between 16 April 2020 and 30 October 2021. Of these 55 patients, 53 (96.4%) completed neoadjuvant therapy, and 48 (87.3%) underwent surgery. The MPR rate was 77.1% [37/48, 95% confidence interval (CI): 62.7-88.0%]. The pCR (ypT0N0) rate was 39.6% (19/48, 95% CI: 25.8-54.7%). All the patients had R0 resections. Primary tumor downstaging occurred in 44 (91.7%) patients, and nodal downstaging occurred in 19 (39.6%) patients. The 2-year DFS rate was 68.9% (95% CI: 53.0-80.4%), and the 2-year OS rate was 74.7% (95% CI: 60.2-84.6%). Grade ≥3 treatment-related adverse events (TRAEs) were observed in 7 (12.7%) patients.
Conclusions: In conclusion, neoadjuvant camrelizumab followed by camrelizumab plus chemotherapy showed promising efficacy in treating locally advanced ESCC and had a manageable safety profile.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11388229 | PMC |
| http://dx.doi.org/10.21037/jtd-24-1141 | DOI Listing |
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