Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11388206 | PMC |
| http://dx.doi.org/10.21037/jtd-24-1172 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Opportunities for More Tailored Approaches to Genotoxicity Testing and Carcinogenicity Strategy for Oligonucleotide Therapeutics: Outcome of an Industry Survey.
Nucleic Acid Ther
January 2025
Global Preclinical Safety, AbbVie Inc., North Chicago, Illinois, USA.
The Oligonucleotide Nonclinical Working Group (WG) of the European Federation of Pharmaceutical Industries and Associations conducted an industry survey to understand current practices and regulatory expectations for genotoxicity and carcinogenicity assessment of oligonucleotide therapeutics (ONTs), along with historical genotoxicity testing results. The survey, involving 29 pharmaceutical and biotechnology companies, revealed a consistent absence of genotoxicity across a diverse range of oligonucleotide classes and chemistries, consistent with previous observations. Despite the lack of genotoxicity, companies continue to follow standard testing guidelines, with only limited divergence.
View Article and Find Full Text PDFA Comparison of Complication Rates in Flexor Tendon Repair Performed in Operating Rooms Versus Clinic-Based Procedure Rooms.
Plast Surg (Oakv)
January 2025
Plastic Surgery Division, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Wide-awake local anesthesia no tourniquet (WALANT) surgery has demonstrated its value in hand surgery allowing surgeons to safely operate patients in different settings outside of a formal operating room (OR). Flexor tendon lacerations have historically been repaired in the controlled setting of an OR. Plastic surgeons at our university-affiliated center have increasingly been performing flexor repairs in clinic-based procedure rooms (PRs).
View Article and Find Full Text PDFCharles R. Drew (1904-1950): A Pioneer of Blood Banking.
Cureus
December 2024
Emergency Medicine and Neurology, University of Central Florida, Orlando, USA.
Dr. Charles Richard Drew, a pioneering figure in modern blood banking and 20th-century medicine, revolutionized blood donation and storage processes, fundamentally shaping the field as we know it today. His extensive work with blood and plasma, combined with an innovative approach to reducing contamination, laid the foundation for modern standards in safety and efficiency.
View Article and Find Full Text PDFUnlocking the therapeutic mechanism of : a comprehensive review of its antioxidant and anti-cancer properties, ethnopharmacology, and phytochemistry.
Front Pharmacol
January 2025
Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Herbal medicine are an invaluable reservoir of bioactive compounds, offering immense potential for novel drug development to address a wide range of diseases. Among these, has gained recognition for its historical medicinal applications and substantial therapeutic potential. This review explores the ethnopharmacological significance, phytochemical composition, and pharmacological properties of , with a particular focus on its anticancer activities.
View Article and Find Full Text PDFIs There Scientific Evidence on the Practice of Rib Resection or Remodeling for Body Contouring Purposes?-A Systematic Review.
Aesthetic Plast Surg
January 2025
Division of Plastic Surgery, Federal University of São Paulo, Rua Botucatu, 740-2º andar, Vila Clementino, São Paulo, SP, Brazil.
Introduction: Rib resection and remodeling have gained attention as cosmetic procedures to enhance body contours, particularly waist-to-hip ratio. Historically, rib resection has been used for medical reasons; however, plastic surgeons have recently adopted it for aesthetic purposes. However, concerns remain regarding the safety and effectiveness of the procedure, particularly due to the potential for complications, such as pneumothorax, chronic pain, and impaired respiratory function.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!