Low back pain significantly impacts individuals' quality of life, with intervertebral disc degeneration (IDD) being a primary contributor to this condition. Currently, IDD treatment primarily focuses on symptom management and does not achieve a definitive cure. The cartilage endplate (CEP), a crucial nutrient-supplying tissue of the intervertebral disc, plays a pivotal role in disc degeneration. This review examines the mechanisms underlying CEP degeneration, summarizing recent advancements in understanding the structure and function of CEP, the involvement of various signaling pathways, and the roles of cartilage endplate stem cells (CESCs) and exosomes (Exos) in this process. The aim of this review is to provide a comprehensive reference for future research on CEP. Despite progress in understanding the role of CEP in IDD, the mechanisms underlying CEP degeneration remain incompletely elucidated. Future research poses significant challenges, necessitating further investigations to elucidate the complexities of CEP.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cbf.4118 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Expression of lipid metabolism and cartilage degeneration-related factors in lumbar vertebral endplate Modic changes.
Jt Dis Relat Surg
January 2025
Department of Orthopaedic Surgery, Affiliated Hospital of Hebei University, No. 212, Yuhua East Road, Baoding 071030, Hebei, China.
Objectives: This study aims to investigate the relationship between the expression of lipid metabolism and cartilage degeneration-related factors and Modic changes (MCs) of lumbar vertebral.
Patients And Methods: This prospective study included a total of 10 patients (6 males, 4 females; mean age: 60.4±8.
The pathogenesis and targeted therapies of intervertebral disc degeneration induced by cartilage endplate inflammation.
Front Cell Dev Biol
December 2024
Department of Spine Surgery and Innovative Laboratory of Orthopedics, Shenzhen Nanshan People's Hospital, Shenzhen, Guangdong, China.
Intervertebral disc degeneration (IVDD) is the leading cause of low back pain, where degeneration and death of nucleus pulposus cells within the intervertebral disc (IVD) can be obviously revealed. This degeneration can result in an imbalance in the extracellular matrix due to the loss of proteoglycans and water content, which can further lead to catabolic and anabolic dysfunction of the IVD. Recently, the dysfunction of cartilage endplate (CEP) during aging has drawn large attention due to its essential functions in contributing nutrient exchange and maintaining IVD homeostasis.
View Article and Find Full Text PDFThe role of loading-induced convection versus diffusion on the transport of small molecules into the intervertebral disc.
Eur Spine J
December 2024
Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Purpose: Limited nutrient transport is hypothesized to be involved in intervertebral disc (IVD) degeneration. It is widely recognized that the dominant mode of transport of small molecules such as glucose is via diffusion, rather than convection. However, recent findings suggest a role for convection-induced by fast (motion-related) and slow (diurnal) dynamic loading in molecular transport of even such small solutes.
View Article and Find Full Text PDFThe clinical results and function of the intersegmental disc after posterior-only partial corpectomy for lumbar burst fractures.
Medicine (Baltimore)
November 2024
Shenzhen Luohu District TCM Hospital, Shen Zhen, China.
We treated the burst spinal fracture with posterior subtotal corpectomy and reconstruction. In some cases, the endplate and the adjacent disc can be preserved during the operation. The adjacent disc retained its mobility after the removal of the posterior pedicle screws.
View Article and Find Full Text PDFWhat can be observed in intervertebral cartilage endplate with aging? An animal model study of excessive axial mechanical loading.
Front Med (Lausanne)
November 2024
Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Introduction: The cartilage endplate (CEP) plays a crucial role as both a mechanical barrier and nutrient channel for the intervertebral disc, but it is vulnerable to excessive axial loading. We modified the Ilizarov external fixator and applied it to the CEP of the rat tail to impose diurnal, controllable excess axial loading. The objective was to measure morphological changes in the CEP when subjected to loading during the aging process.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!