AI Article Synopsis

  • The THαβ host immunological pathway plays a crucial role in how the body responds to infections, particularly from viruses and prions.
  • There is growing evidence linking the THαβ immune response to various autoimmune diseases, especially type 2 hypersensitivity disorders like systemic lupus erythematosus and myasthenia gravis.
  • Potential new treatments targeting components of the THαβ pathway, such as anti-interleukin-10 or anti-interferon α/β, could be valuable for managing these autoimmune conditions.

Article Abstract

The THαβ host immunological pathway contributes to the response to infectious particles (viruses and prions). Furthermore, there is increasing evidence for associations between autoimmune diseases, and particularly type 2 hypersensitivity disorders, and the THαβ immune response. For example, patients with systemic lupus erythematosus often produce anti-double stranded DNA antibodies and anti-nuclear antibodies and show elevated levels of type 1 interferons, type 3 interferons, interleukin-10, IgG1, and IgA1 throughout the disease course. These cytokines and antibody isotypes are associated with the THαβ host immunological pathway. Similarly, the type 2 hypersensitivity disorders myasthenia gravis, Graves' disease, graft-versus-host disease, autoimmune hemolytic anemia, immune thrombocytopenia, dermatomyositis, and Sjögren's syndrome have also been linked to the THαβ pathway. Considering the potential associations between these diseases and dysregulated THαβ immune responses, therapeutic strategies such as anti-interleukin-10 or anti-interferon α/β could be explored for effective management.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11409508PMC
http://dx.doi.org/10.1080/21505594.2024.2404225DOI Listing

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