The inability to identify dates of death in insurance claims data is the United States is a major limitation to retrospective claims-based research. While deaths result in disenrollment, disenrollment can also occur due to changes in insurance providers. We created an algorithm to differentiate between disenrollment from health plans due to death and disenrollment for other reasons. We identified 5,259,735 adults who disenrolled from private insurance between 2007 and 2018. Using death dates ascertained from the Social Security Death Index, inpatient discharge status, and death indicators in the administrative data, 7.6% of all disenrollments were classified as resulting from death. We used elastic net regression to build an algorithm using claims data in the year prior to disenrollment; candidate predictors included medical conditions, individual demographic characteristics, treatment utilization, and structural factors related to health insurance eligibility and coding. Using a predicted probability threshold of 0.9 (selected to reflect the corresponding known prevalence of mortality), internal validation found that the algorithm classified death at disenrollment with a positive predictive value of 0.815, sensitivity of 0.721 and specificity of 0.986 (AUC=0.97). Independent data sources were used for external validation and for an applied example. Code for implementation is publicly available.
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http://dx.doi.org/10.1093/aje/kwae348 | DOI Listing |
Public Underst Sci
January 2025
Radboud University, The Netherlands; University of Gothenburg, Sweden; Leibniz University Hannover, Germany.
Citizens' trust in science increasingly depends on their political leaning. Structural equation models on survey data from 10 European countries ( = 5306) demonstrate that this can be captured by a model with four levels of generalization. Voters of populist parties distrust the in general, which indirectly fuels a broad science skepticism.
View Article and Find Full Text PDFWorld J Surg
January 2025
Precision Medicine Program, Hoag Family Cancer Institute, Newport Beach, California, USA.
Background: A recent prospective phase II study (ECOG-ACRIN E2211) demonstrated that MGMT deficiency was associated with a significant response to capecitabine and temozolomide (CAPTEM) in pancreatic neuroendocrine neoplasms (NENs); however, routine MGMT analysis in NENs was not recommended. Our study sought to demonstrate whether loss of MGMT protein expression is associated with improved overall survival (OS) in patients receiving CAPTEM for NENs from various tumor sites.
Materials And Methods: Paraffin-embedded tumor samples were evaluated by immunohistochemistry (IHC) using an MGMT monoclonal antibody.
Patient Saf Surg
January 2025
NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
Background: Meniscal surgery is one of the most frequent orthopaedic procedures performed worldwide. There is a wide range of possible treatment errors that can occur following meniscal surgery. In Norway, patients subject to treatment errors by hospitals and private institutions can file a compensation claim free of charge to the Norwegian System of Patient Injury Compensation (NPE).
View Article and Find Full Text PDFJ Gen Intern Med
January 2025
School of Public Health, Division of Health Policy and Management, University of California, Berkeley, Berkeley, CA, USA.
Background: External incentives increasingly encourage hospitals to address health-related social needs, yet limited evidence exists about whether social needs interventions are associated with quality indicators like potentially preventable admissions.
Objective: We analyze whether four hospital interventions-meal delivery, transportation to health services, mobile clinics, and community-oriented violence prevention programs-are associated with potentially preventable hospitalizations.
Design: Cross-sectional analysis of survey-based and claims-based data.
Sci Rep
January 2025
Research and Development, Aesculap AG, Tuttlingen, Germany.
In clinical movement biomechanics, kinematic measurements are collected to characterise the motion of articulating joints and investigate how different factors influence movement patterns. Representative time-series signals are calculated to encapsulate (complex and multidimensional) kinematic datasets succinctly. Exacerbated by numerous difficulties to consistently define joint coordinate frames, the influence of local frame orientation and position on the characteristics of the resultant kinematic signals has been previously proven to be a major limitation.
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