AI Article Synopsis
- The article explores the role of short-chain fatty acids (SCFAs) in Parkinson's disease (PD), noting their production through gut microbiota fermentation of dietary fiber.
- It highlights the links between SCFAs, gut-brain axis dysfunction, and neuroinflammation, all of which are relevant to PD development.
- The study suggests that SCFAs could be valuable in managing PD by improving gut health, reducing neuroinflammation, and enhancing neuronal survival, based on a thorough literature review.
Article Abstract
The emerging function of short-chain fatty acids (SCFAs) in Parkinson's disease (PD) has been investigated in this article. SCFAs, which are generated via the fermentation of dietary fiber by gut microbiota, have been associated with dysfunction of the gut-brain axis and, neuroinflammation. These processes are integral to the development of PD. This article examines the potential therapeutic implications of SCFAs in the management of PD, encompassing their capacity to modulate gastrointestinal permeability, neuroinflammation, and neuronal survival, by conducting an extensive literature review. As a whole, this article emphasizes the potential therapeutic utility of SCFAs as targets for the management and treatment of PD.
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| http://dx.doi.org/10.1007/s10048-024-00779-3 | DOI Listing |
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