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Sesamin alleviates lipid accumulation induced by elaidic acid in L02 cells through TFEB regulated autophagy.
Front Nutr
December 2024
School of Public Health, Shandong Second Medical University, Weifang, China.
Introduction: Non-alcoholic fatty liver disease (NAFLD) is a common chronic disease seriously threatening human health, with limited treatment means, however. Sesamin, a common lignan in sesame seed oil, exhibits anti-inflammatory, antioxidant, and anticancer properties. Our previous studies have shown an ameliorative effect of sesamin on lipid accumulation in human hepatocellular carcinoma (HePG2) induced by oleic acid, with its protective effects unclear in the case of 9-trans-C18:1 elaidic acid (9-trans-C18,1).
View Article and Find Full Text PDFChronic immune thrombocytopenic purpura in children: Clinical presentations and management.
Tunis Med
November 2024
Department of Pediatrics, Hedi Chaker Hospital, Sfax, Tunisia.
Article Synopsis
- This study focuses on chronic immune thrombocytopenic purpura (ITP) in children, reporting on epidemiological data and clinical management from a pediatric department in southern Tunisia over 13 years.
- Out of 72 newly diagnosed ITP cases, 11 evolved into chronic ITP, with a mix of symptoms and complications, including two patients who experienced severe cases requiring advanced treatment.
- The findings highlight the difficulties pediatricians face in managing chronic ITP, emphasizing the importance of existing guidelines to assist in treatment strategies for severe cases.
Concurrent Guillain-Barre/acute transverse myelitis overlap syndrome after COVID-19 infection in a patient with ITP: A case report.
Medicine (Baltimore)
November 2024
Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Article Synopsis
- Patients with chronic immune diseases, like ITP, need to be particularly cautious of GBS/ATM overlap syndrome following a COVID-19 infection.
- A 65-year-old man with ITP developed symptoms like limb weakness and facial paralysis two weeks post-COVID-19 diagnosis and was diagnosed with GBS/ATM overlap syndrome.
- After receiving treatment with intravenous immune globulin and other medications, he showed significant improvement and resumed normal activities, even successfully battling a second COVID-19 infection five months later with milder symptoms.
Experience with Pediatric Chronic Immune Thrombocytopenia over 30 Years in the Era before Eltrombopag.
Children (Basel)
August 2024
Department of Pediatric Hematology and Oncology, Istinye University, Istanbul 34320, Turkey.
Background: There is limited information on the natural course of chronic ITP in children. We aimed to evaluate the clinical and demographic characteristics of children with chronic ITP in the era before the availability of eltrombopag.
Methods: A total of 86 children with chronic ITP between 1978-2014 were included.
Eltrombopag in chronic myelomonocytic leukemia with severe thrombocytopenia. A Groupe Francophone des Myélodysplasies (GFM) study.
Leukemia
November 2024
Hematology Department, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, F-75010, Paris, France.
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