AI Article Synopsis
- Acute aortic dissection (AD) in pregnancy poses a significant threat to both mothers and babies, but there's a lack of established treatment guidelines.
- A study analyzed data from 67 women with AD during pregnancy or shortly after, revealing that immediate surgery is critical for type A AD cases, which accounted for nearly 69% of the participants.
- The results highlighted a maternal mortality rate of 10.4% and a fetal mortality rate of 26.9%, suggesting that immediate surgical intervention drastically reduces the risks of death for both mother and fetus compared to selective surgery.
Article Abstract
Background: Acute aortic dissection (AD) in pregnancy poses a lethal risk to both mother and fetus. However, well-established therapeutic guidelines are lacking. This study aimed to investigate clinical features, outcomes and optimal management strategies for pregnancy-related AD.
Methods: We conducted a retrospective multicentre cohort study including 67 women with acute AD during pregnancy or within 12 weeks postpartum from three major cardiovascular centres in China between 2003 and 2021. Patient characteristics, management strategies and short-term outcomes were analysed.
Results: Median age was 31 years, with AD onset at median 32 weeks gestation. Forty-six patients (68.7%) had type A AD, of which 41 underwent immediate surgery. Overall maternal mortality was 10.4% (7/67) and fetal mortality was 26.9% (18/67). Compared with immediate surgery, selective surgery was associated with higher risk of composite maternal and fetal death (adjusted RR: 12.47 (95% CI 3.26 to 47.73); p=0.0002) and fetal death (adjusted RR: 8.77 (95% CI 2.33 to 33.09); p=0.001).
Conclusions: Immediate aortic surgery should be considered for type A AD at any stage of pregnancy or postpartum. For pregnant women with AD before fetal viability, surgical treatment with the fetus in utero should be considered. Management strategies should account for dissection type, gestational age, and fetal viability.
Trial Registration Number: NCT05501145.
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Source |
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| http://dx.doi.org/10.1136/heartjnl-2024-324009 | DOI Listing |
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