AI Article Synopsis
- The study aimed to investigate how sleep quality impacts ovarian reserve in women aged 20-40, using a cross-sectional design with 1,070 participants.
- Results indicated that 29.35% of participants had poor sleep quality, which correlated with lower levels of antimüllerian hormone (AMH) and antral follicle count (AFC), and higher follicle-stimulating hormone (FSH) levels.
- The analysis suggested that worse sleep quality significantly increased the odds of having diminished ovarian reserve, with those in the poor sleep group being 4.43 times more likely to experience this compared to those with better sleep.
Article Abstract
Objective: To evaluate the association between sleep quality and ovarian reserve among women of reproductive age.
Design: Cross-sectional study.
Setting: Not applicable.
Patient(s): A total of 1,070 female participants aged 20-40 years enrolled from February 2023 to January 2024.
Intervention(s): Not applicable.
Main Outcome Measure(s): A questionnaire was administered to the participants to collect baseline information related to reproductive and lifestyle factors. Pittsburgh Sleep Quality Index (PSQI) was used to measure sleep quality. The assessment was conducted on ovarian reserve, including total antral follicle count (AFC), antimüllerian hormone (AMH) level, and basal sex hormone level.
Result(s): The study sample of 1,070 women had a mean age of 31.67 ± 4.41 years. A total of 314 participants (29.35%) were classified under the poor sleep group (PSQI score >5). Significant differences were observed in the follicle-stimulating hormone (FSH), luteinizing hormone, estradiol, testosterone, AFC, and AMH between the two groups. The poor sleep group exhibited significantly lower levels of AMH and AFC. The FSH levels in the poor sleep group were higher. After the adjustment for confounding factors, multivariate regression analysis results indicated that the per unit increase in PSQI score was associated with increased odds of diminished ovarian reserve (adjusted odds ratio [AOR] of 1.28 for AMH <1.1 ng/mL; 95% confidence interval [CI], 1.20-1.37; AFC <7; AOR, 1.34; 95% CI, 1.25-1.43; FSH ≥10 mIU/mL; AOR, 1.16; 95% CI, 1.08-1.25; AMH <1.1 ng/mL or AFC <7 or FSH ≥10 mIU/mL; AOR, 1.29; 95% CI, 1.22-1.37). Compared with the PSQI ≤5 group, subjects with PSQI >5 had increased odds of diminished ovarian reserve (odds ratio, 3.80; 95% CI, 2.82-5.13; AOR, 4.43; 95% CI, 3.22-6.14). After stratification by age and body mass index, compared with the PSQI ≤5 group, all subgroups of the PSQI >5 group had increased odds of diminished ovarian reserve, especially <35-year-old and body mass index ≤18.4 kg/m subgroups.
Conclusion(s): Poor sleep quality is associated with diminished ovarian reserve in women of reproductive age.
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| http://dx.doi.org/10.1016/j.fertnstert.2024.09.018 | DOI Listing |
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