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Respiratory syncytial virus vaccination and immunoprophylaxis: realising the potential for protection of young children. | LitMetric

AI Article Synopsis

  • The search for effective ways to prevent respiratory syncytial virus (RSV) in infants has continued for over 60 years, leading to the approval of two new products in higher-income countries: a monoclonal antibody called nirsevimab and a maternal vaccine known as RSVpreF.
  • These products are currently unavailable in low-income regions, where most RSV-related deaths occur, highlighting a significant global health disparity.
  • The paper also reviews the safety and effectiveness of these treatments, discusses potential implementation strategies in various countries, and emphasizes that with political commitment and affordable pricing, preventing RSV in infants could be achievable worldwide.

Article Abstract

The search for safe and efficacious products to prevent severe respiratory syncytial virus (RSV) disease in young infants has lasted more than 60 years. In high-income and middle-income countries, two new products have been authorised: an RSV monoclonal antibody for administration to infants (nirsevimab) and an RSV prefusion F maternal vaccine (RSVpreF [Pfizer, Puurs, Belgium]) for administration to pregnant people. These products are not yet available in low-income and lower-middle-income countries, where most RSV deaths occur. Other papers in this Series describe the acute burden of RSV disease in young children, the effects of RSV infection in early childhood on long-term lung health, and the burden of RSV disease and disease prevention products in older adults. In this Series paper, we briefly review the efficacy, effectiveness, and safety of nirsevimab and RSVpreF maternal vaccine for protection of infants. We then explore potential regulatory, policy, and implementation pathways and provide case studies of intervention uptake in Spain and Argentina, and considerations for use in Kenya. We also explore the health economic evidence to inform product introduction decisions. With sufficient political will and affordable pricing, RSV disease prevention in infants can become a global reality.

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Source
http://dx.doi.org/10.1016/S0140-6736(24)01699-4DOI Listing

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