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Cardiac mechano-electric crosstalk: multi-scale observations, computational integration, and clinical implications.
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Department of Physiology and Biophysics, Dalhousie University, Halifax, Canada.
Suppression of Contraction Raises Calcium Ion Levels in the Heart of Zebrafish Larvae.
Biosensors (Basel)
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Physiology and Cell Dynamics Group, Instituto de Biomedicina de la Universidad de Castilla-La Mancha, Facultad de Medicina de Albacete, Universidad de Castilla-La Mancha, C/Almansa 14, 02006 Albacete, Spain.
Article Synopsis
- Zebrafish larvae are becoming important models for understanding heart function and disease due to their transparency, which helps with imaging techniques, but heart movement can cause challenges in fluorescence imaging.
- Researchers have tested two methods to prevent heart motion—using genetic knockdowns and myosin inhibitors—but these methods interfere with heart function and calcium regulation.
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A tribute to Dr Frederick Sachs.
J Physiol
September 2024
Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, USA.
Recurrence of ventricular fibrillation in out-of-hospital cardiac arrest: Clinical evidence and underlying ionic mechanisms.
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ZOLL Medical, Chelmsford, Massachusetts, USA.
Defibrillation remains the optimal therapy for terminating ventricular fibrillation (VF) in out-of-hospital cardiac arrest (OHCA) patients, with reported shock success rates of ∼90%. A key persistent challenge, however, is the high rate of VF recurrence (∼50-80%) seen during post-shock cardiopulmonary resuscitation (CPR). Studies have shown that the incidence and time spent in recurrent VF are negatively associated with neurologically-intact survival.
View Article and Find Full Text PDFDifferential effects of mechano-electric feedback mechanisms on whole-heart activation, repolarization, and tension.
J Physiol
September 2024
Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
The human heart is subject to highly variable amounts of strain during day-to-day activities and needs to adapt to a wide range of physiological demands. This adaptation is driven by an autoregulatory loop that includes both electrical and the mechanical components. In particular, mechanical forces are known to feed back into the cardiac electrophysiology system, which can result in pro- and anti-arrhythmic effects.
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