AI Article Synopsis
- Longevity in families has both genetic and epigenetic factors, and studying these aspects can benefit from a birth cohort approach.
- The original family longevity selection score (FLoSS) primarily focuses on older populations, but researchers adapted it for a younger cohort, specifically the KUNO-Kids study.
- In this study, 551 families contributed to the new FLoSS, revealing that around 3.3% of families scored exceptionally high, suggesting that this adapted score could be useful for identifying early predictors of longevity in a broader context.
Article Abstract
Longevity accumulating in families has genetic and epigenetic components. To study early and unbiased epigenetic predictors of longevity prospectively, a birth cohort would be ideal. However, the original family longevity selection score (FLoSS) focuses on populations of elderly only. In the German birth cohort KUNO-Kids we assessed when information for such scores may be best collected and how to calculate an adapted FLoSS. A total of 551 families contributed to adapted FLoSS, with a mean score of -0.15 (SD 2.33). Adapted FLoSS ≥7 as a marker of exceptional longevity occurred in 3.3% of families, comparable to original FLoSS in elderly. An adapted FLoSS from data collectable postnatally may be a feasible tool to study unbiased epigenetic predictors for longevity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457659 | PMC |
| http://dx.doi.org/10.1080/17501911.2024.2370760 | DOI Listing |
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