AI Article Synopsis
- Nitric oxide (NO) is important for regulating biological functions and has potential as a treatment for chronic diseases.
- Metal-organic frameworks (MOFs) are being explored as carriers for NO, but challenges exist in delivering it effectively due to quick degradation and water replacement issues.
- A new type of MOF, MIP-210(Fe), shows a unique ability to hold and release NO slowly in biological fluids, allowing for effective delivery of NO for over 70 hours, which is significantly longer than other materials.
Article Abstract
Nitric oxide (NO), a key element in the regulation of essential biological mechanisms, presents huge potential as therapeutic agent in the treatment and prevention of chronic diseases. Metal-organic frameworks (MOFs) with open metal sites are promising carriers for NO therapies but delivering it over an extended period in biological media remains a great challenge due to i) a fast degradation of the material in body fluids and/or ii) a rapid replacement of NO by water molecules onto the Lewis acid sites. Here, a new ultra-narrow pores Fe bisphosphonate MOF, denoted MIP-210(Fe) or Fe(HO)(Hmbpa) (Hmbpa = p-xylenediphosphonic acid) is described that adsorbs NO due to an unprecedented sorption mechanism: coordination of NO through the Fe(III) sites is unusually preferred, replacing bound water, and creating a stable interaction with the free HO and P-OH groups delimiting the ultra-narrow pores. This, associated with the high chemical stability of the MOF in body fluids, enables an unprecedented slow replacement of NO by water molecules in biological media, achieving an extraordinarily extended NO delivery time over at least 70 h, exceeding by far the NO kinetics release reported with others porous materials, paving the way for the development of safe and successful gas therapies.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600697 | PMC |
| http://dx.doi.org/10.1002/smll.202405649 | DOI Listing |
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