AI Article Synopsis

  • The posterior fossa is a small area in the brain that, when affected by tumors or lesions, can lead to severe neurological issues due to pressure on vital structures and fluid buildup (hydrocephalus).
  • Urgent surgical intervention is typically necessary, and neuro-oncologists play a crucial role in helping patients and families navigate treatment options and understand long-term outcomes.
  • Advances in molecular classifications and high-dose radiation therapy have the potential to enhance survival rates and quality of life, with different tumors commonly affecting children (like ependymomas and medulloblastomas) versus adults (who often have metastatic disease).

Article Abstract

The posterior fossa is a limited compartment therefore lesions compressing its structures can result in devastating outcomes. It can cause significant neurological deficit due to mass effect on critical structures and hydrocephalus. Due to the nature of the infratentorial region, urgent surgical intervention is often the first-line option. Surgical neuro-oncologists guide patients and caregivers through the course of this disease and to inform them about the various options for management and long-term outcome optimisation. There is currently conflicting data; however, institutional experiences can guide us towards achieving improvements in surgical outcomes and quality of life. Advances in molecular classifications coupled with highdose radiation treatment improve our capacity for improving overall survival in these patients. Common childhood tumours are ependymomas, medulloblastomas, and juvenile pilocytic astrocytomas, while adults often present with metastases, and less commonly, cerebellar haemangioblastomas and gliomas. This paper outlines management strategies with consideration for multidisciplinary care and resourcelimited settings.

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Source
http://dx.doi.org/10.47391/JPMA.S3.GNO-22DOI Listing

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