AI Article Synopsis

  • - A 65-year-old man receiving treatment for liver cancer developed severe symptoms including fever, movement difficulties, and aphasia, leading to coma upon hospital admission.
  • - After conducting tests that showed no malignancy or infection, he was diagnosed with encephalitis as a side effect of his treatment with atezolizumab and bevacizumab.
  • - Following steroid pulse therapy, the patient regained consciousness and mobility but experienced slight leg paralysis, ultimately being discharged to continue chemotherapy, highlighting the importance of early diagnosis and treatment for better outcomes in cases of encephalitis.

Article Abstract

A 65-year-old man treated with atezolizumab plus bevacizumab for hepatocellular carcinoma was admitted to our hospital with a fever, difficulty in moving, and aphasia. The patient became comatose immediately after admission. Imaging and cerebral fluid tests revealed no evidence of malignancy or infection. A diagnosis of atezolizumab-induced encephalitis was made, and steroid pulse therapy was initiated on admission, immediately after which the patient regained consciousness and was able to talk and walk. He was discharged with slight paralysis of his legs and was able to resume chemotherapy. An early diagnosis and treatment are required to improve the prognosis of encephalitis.

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Source
http://dx.doi.org/10.2169/internalmedicine.4321-24DOI Listing

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