AI Article Synopsis
- The interplay between hydrogen sulfide (HS) and microRNA (miRNA) plays a significant role in various diseases, such as cancer, cardiovascular issues, inflammatory conditions, and problematic pregnancies.
- Abnormal levels of HS-producing enzymes and miRNA in cells can signal the presence of disease; maintaining their normal levels may reduce the damage caused by these illnesses.
- HS has been found to both promote cancer cell behaviors like migration and invasion and inhibit cancer progression through certain HS donors, while also helping in fetal development during high-risk pregnancies by improving blood flow and growth factors.
Article Abstract
The mutual regulation between hydrogen sulfide (HS) and microRNA (miRNA) is involved in the development of many diseases, including cancer, cardiovascular disease, inflammatory disease, and high-risk pregnancy. Abnormal expressions of endogenous HS-producing enzyme and miRNA in tissues and cells often indicate the occurrence of diseases, so the maintenance of their normal levels in the body can mitigate damages caused by various factors. Many studies have found that HS can promote the migration, invasion, and proliferation of cancer cells by regulating the expression of miRNA, while many HS donors can inhibit cancer progression by interfering with the proliferation, apoptosis, cell cycle, metastasis, and angiogenesis of cancer cells. Furthermore, the mutual regulation between HS and miRNA can also prevent cell injury in cardiovascular disease and inflammatory disease through anti-inflammation, anti-oxidation, anti-apoptosis, and pro-autophagy. In addition, HS can promote angiogenesis and relieve vasoconstriction by regulating the expression of miRNA, thereby improving fetal growth in high-risk pregnancy. In this review, we discuss the mechanism of mutual regulation between HS and miRNA in various diseases, which may provide reliable therapeutic targets for these diseases.
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| http://dx.doi.org/10.1016/j.niox.2024.09.002 | DOI Listing |
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