AI Article Synopsis
- * A selection of six branched peptides, designed to improve resistance to proteases and boost efficacy, was tested for antibacterial activity, biofilm inhibition, cytotoxicity, and resistance to breakdown.
- * The peptide BAMP2 demonstrated encouraging results in treating mouse skin infections, suggesting its potential for local application in infection management.
Article Abstract
Antibiotic resistance is a major global health threat, necessitating the development of new treatments and diverse molecules to combat severe infections and preserve the efficacy of existing drugs. Antimicrobial peptides (AMPs) offer a versatile arsenal against bacteria, and peptide structure branching can enhance their resistance to proteases and improve their overall efficacy. A small library of peptides derived from natural host defense peptides and synthesized in a tetrabranched form was selected against . Six selected branched peptides were further studied for antibacterial activity against a panel of strains, biofilm inhibition, protease resistance, and cytotoxicity. Their structure was predicted computationally and their mechanism of action was investigated by electron microscopy and by using fluorescent dyes. The peptide BAMP2 showed promise in a mouse skin infection model, indicating the potential for local infection treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440494 | PMC |
| http://dx.doi.org/10.1021/acs.jmedchem.4c00810 | DOI Listing |
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