AI Article Synopsis
- Aging contributes to changes that worsen various diseases throughout life, particularly affecting the central nervous system (CNS).
- It specifically impacts the ability to repair myelin sheaths, which are crucial for efficient neuronal signaling.
- A study by Tiwari et al. indicates that aging-related changes in microglia after demyelination can potentially be reversed through epigenetic modifications following BCG vaccination.
Article Abstract
Aging leads to alterations that precipitate or aggravate several diseases that occur across our lifespan. In the CNS, aging affects the capacity to maintain and repair the myelin sheaths that protect axons and facilitate neuronal signaling. Tiwari et al. report aging-associated transcriptional responses in microglia after demyelination, which could be reversed by epigenetic remodeling after BCG vaccination.
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| http://dx.doi.org/10.1016/j.immuni.2024.08.001 | DOI Listing |
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Article Synopsis
- Aging contributes to changes that worsen various diseases throughout life, particularly affecting the central nervous system (CNS).
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