Dose falls-off faster than the inverse square law (ISL) for orthovoltage beams with closed-ended applicators. This work investigates the discrepancy for 30 cm FSD applicators. When using the ISL alone, the maximum dosimetric error would be 3% and 5% at 10 mm and 20 mm from the applicator, respectively, and increases with larger distances. The effective source position was found to be 22.5 cm and reduces the dosimetric error to less than 1.6% for distances less than 20 mm.
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http://dx.doi.org/10.1016/j.apradiso.2024.111514 | DOI Listing |
Clin Trials
January 2025
Department of Biostatistics, University of Washington, Seattle, WA, USA.
Background: N-of-1 trials compare two or more treatment options for a single participant. These trials have been used to study options for chronic conditions such as arthritis and attention deficit hyperactivity disorder. In addition, they have been suggested as a means to study interventions in rare populations that may not be tractable to include in standard clinical trials, such as treatment options for HIV-positive patients in need of organ transplant.
View Article and Find Full Text PDFBreast J
January 2025
Malaria Alert Centre Kamuzu University of Health Sciences, Private Bag 360, Chichiri, Blantyre 3, Malawi.
Introduction: Breast cancer is currently the most frequently detected cancer in women and the primary cause of cancer-related deaths globally. The incidence of breast cancer has significantly increased in countries across sub-Saharan Africa, counting Ethiopia. There are multiple determinants of breast cancer, a few of these can be changeable whereas others are not.
View Article and Find Full Text PDFNetw Neurosci
December 2024
Neuroradiology Group, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.
Multiple sclerosis (MS) is a neurodegenerative disease that affects the central nervous system. Structures affected in MS include the corpus callosum, connecting the hemispheres. Studies have shown that in mammalian brains, structural connectivity is organized according to a conservation principle, an inverse relationship between intra- and interhemispheric connectivity.
View Article and Find Full Text PDFCurr Oncol
November 2024
Anatomical Pathology Laboratory, Hasanuddin University Hospital, Makassar 90245, Indonesia.
Aim: Colorectal cancer (CRC) is a prevalent malignancy with a high mortality rate. Tumor-infiltrating lymphocytes (TILs) play a crucial role in the immune response against tumors. Programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) are key immune checkpoints regulating T cells in the tumor microenvironment.
View Article and Find Full Text PDFProbl Radiac Med Radiobiol
December 2024
State Institution «National Research Center of Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka Str., Kyiv, 04050, Ukraine.
Objective: Evaluation of structural features and metabolic/biochemical abnormalities of the bone tissue and relevant regulation patterns in children, residing in the radiologically contaminated territories (RCT).
Materials And Methods: Children (n = 148) aged 7 to 18 years old were involved in the study. Bone mineral density (BMD) is given in 3 grades according to the mean square deviation values, namely Grade I - standard (n = 75),Grade II - reduced (n = 45) and Grade III - very low one (n = 28).
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