AI Article Synopsis
- - Disseminated non-tuberculous mycobacterial (NTM) infections can severely impact patients with weakened immune systems, potentially leading to serious conditions like hemophagocytic syndrome (HPS) if not diagnosed quickly.
- - A case study involved a 63-year-old woman with suspected autoimmune disease who met the criteria for HPS, with Mycobacterium avium isolated from multiple sources including blood and bone marrow.
- - For better treatment outcomes in immunocompromised patients, early detection of mycobacterial infections and HPS, along with appropriate lab testing for drug resistance, is crucial.
Article Abstract
Disseminated non-tuberculous mycobacterial (NTM) infection can affect patients with underlying immunosuppressive conditions. Despite being rare, delay in diagnosis can lead to life-threatening uncontrolled immune response and hemophagocytic syndrome (HPS). We report a case of a 63-year-old female with suspected autoimmune disease, in whom HPS was diagnosed according to HLH-2004 criteria and H-score. Mycobacterium avium (M. avium) was isolated from blood culture, bronchoalveolar lavage (BAL) and bone marrow biopsy. In immunosuppressed patients, early clinical suspicion and prompt microbiological diagnosis of mycobacterial infection together with drug susceptibility tests (DST)-based treatment, as well as HPS, are pivotal to increase the likelihood of treatment success.
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| http://dx.doi.org/10.1016/j.diagmicrobio.2024.116528 | DOI Listing |
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