Metabolic Flux Modeling in Marine Ecosystems.

Ann Rev Mar Sci

1Bioinformatics Program, Faculty of Computing and Data Science, Boston University, Boston, Massachusetts, USA; email:

Published: September 2024

AI Article Synopsis

  • Ocean metabolism involves complex biochemical reactions among various organisms in marine environments.
  • To understand these processes quantitatively, researchers use mathematical tools like flux balance analysis, which helps solve the resource allocation challenges cells face.
  • This method has been useful in studying marine organisms, nutrient cycling, and predicting metabolic functions, with potential for enhancing knowledge about marine ecosystems and their sustainability.

Article Abstract

Ocean metabolism constitutes a complex, multiscale ensemble of biochemical reaction networks harbored within and between the boundaries of a myriad of organisms. Gaining a quantitative understanding of how these networks operate requires mathematical tools capable of solving in silico the resource allocation problem each cell faces in real life. Toward this goal, stoichiometric modeling of metabolism, such as flux balance analysis, has emerged as a powerful computational tool for unraveling the intricacies of metabolic processes in microbes, microbial communities, and multicellular organisms. Here, we provide an overview of this approach and its applications, future prospects, and practical considerations in the context of marine sciences. We explore how flux balance analysis has been employed to study marine organisms, help elucidate nutrient cycling, and predict metabolic capabilities within diverse marine environments, and highlight future prospects for this field in advancing our knowledge of marine ecosystems and their sustainability.

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http://dx.doi.org/10.1146/annurev-marine-032123-033718DOI Listing

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