AI Article Synopsis
- * Recent findings indicate that this bacteria has a preference for acquiring fatty acids from hosts rather than synthesizing them itself, leading to increased lipid levels in infected mice.
- * Although there are links between fatty acid uptake and certain bacterial processes, such as vesicle production, these do not affect the bacteria's overall structure or susceptibility to antibiotics, highlighting a complex relationship between bacterial survival strategies and host factors, particularly in obese individuals.
Article Abstract
is consistently ranked among the most problematic multidrug-resistant bacterial pathogens in healthcare systems. Developing novel treatments requires a better understanding of its interaction with the host environment. Although bacteria can synthesize fatty acids, emerging findings suggest a potential preference for their acquisition from the host. Fatty acid profiling of mice revealed a dramatic increase in the level of hepatic lipids during . infection. The . fatty acid composition and uptake capabilities were found to be largely clonally conserved. Correlations between fatty acid uptake, outer membrane vesicle production, and cell permeability were observed, but this did not translate to alterations in cell morphology, capsule production, or antimicrobial susceptibility. Importantly, hyper-capsulation did not prevent the uptake of hydrophobic fatty acids. The uptake of a saturated fatty acid by hypervirulent . isolate may provide insights into the clinical association of . infections with hyperlipidemic and/or obese individuals.
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| http://dx.doi.org/10.1021/acsinfecdis.4c00307 | DOI Listing |
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