AI Article Synopsis
- - This study aimed to explore large somas presumed to be displaced retinal ganglion cells (dRGCs) in the living human retina, focusing on their presence and characteristics in both healthy individuals and those with glaucoma.
- - Researchers used advanced imaging techniques on eight subjects to measure the density, size, and distribution of these somas across different retinal locations, noting significant differences between healthy individuals and glaucoma patients.
- - Findings indicated that these somas are likely dRGCs, showing a high susceptibility to glaucoma-related damage, particularly in areas affected by arcuate defects in glaucoma patients.
Article Abstract
Purpose: The purpose of this study was to investigate the large somas presumed to be displaced retinal ganglion cells (dRGCs) located in the inner nuclear layer (INL) of the living human retina. Whereas dRGCs have previously been studied in mammals and human donor tissue, they have never been investigated in the living human retina.
Methods: Five young, healthy subjects and three subjects with varying types of glaucoma were imaged at multiple locations in the macula using adaptive optics optical coherence tomography. In the acquired volumes, bright large somas at the INL border with the inner plexiform layer were identified, and the morphometric biomarkers of soma density, en face diameter, and spatial distribution were measured at up to 13 degrees retinal eccentricity. Susceptibility to glaucoma was assessed.
Results: In the young, healthy individuals, mean density of the bright, large somas was greatest foveally (550 and 543 cells/mm2 at 2 degrees temporal and nasal, respectively) and decreased with increasing retinal eccentricity (38 cells/mm2 at 13 degrees temporal, the farthest we measured). Soma size distribution showed the opposite trend with diameters and size variation increasing with retinal eccentricity, from 12.7 ± 1.8 µm at 2 degrees to 15.7 ± 3.5 µm at 13 degrees temporal, and showed evidence of a bimodal distribution in more peripheral locations. Within and adjacent to the arcuate defects of the subjects with glaucoma, density of the bright large somas was significantly lower than found in the young, healthy individuals.
Conclusions: Our results suggest that the bright, large somas at the INL border are likely comprised of dRGCs but amacrine cells may contribute too. These somas appear highly susceptible to glaucomatous damage.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11401130 | PMC |
| http://dx.doi.org/10.1167/iovs.65.11.20 | DOI Listing |
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