AI Article Synopsis
- Dysregulation of neutrophil extracellular traps (NETs) has been linked to several inflammatory rheumatic diseases, highlighting their importance in these conditions.
- Recent findings show that NET formation is increased in patients with large vessel vasculitis and polymyalgia rheumatica, and NETs may have harmful effects in affected tissues.
- There's potential for using NETs and anti-NET antibodies as biomarkers for disease, and more research is needed on how altering NET formation and clearance could impact treatment for these diseases.
Article Abstract
Purpose Of Review: Dysregulation in neutrophil extracellular trap (NET) formation and degradation has been reported in several inflammatory rheumatic diseases. This review summarizes the recent advances in the understanding the role of NETs in the context of inflammatory rheumatic diseases.
Recent Findings: NET formation is enhanced in peripheral blood of patients with large vessel vasculitis and polymyalgia rheumatica. NETs are detected in affected organs in autoimmune conditions, and they might play pathological roles in tissues. Several understudied medications and supplements suppress NET formation and ameliorate animal models of inflammatory rheumatic diseases. NETs and anti-NET antibodies have potential utility as disease biomarkers.
Summary: Growing evidence has suggested the contribution of NET dysregulation to the pathogenesis of several inflammatory rheumatic diseases. Further research is warranted in regard to clinical impact of modulating aberrant NET formation and clearance in inflammatory rheumatic diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11602361 | PMC |
| http://dx.doi.org/10.1097/BOR.0000000000001054 | DOI Listing |
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