AI Article Synopsis
- Recent population studies suggest that viral infections, like influenza and COVID-19, may increase the risk of ischemic stroke, although the exact mechanisms remain unclear.
- The review highlights how interactions between viruses and hosts can directly affect vascular function, inflammation, and thrombosis, contributing to stroke incidence.
- It emphasizes the need for more research to understand these mechanisms better and encourages the development of targeted prevention strategies for stroke linked to viral infections.
Article Abstract
Population studies have suggested that viral infections may be contributing to risk of ischemic stroke, although the mechanisms for this are unclear. In this review, we examine the epidemiological evidence supporting the involvement of viral diseases, including influenza, COVID-19, chronic herpesvirus infections, and hepatitis C in current trends of stroke incidence. To support these associations, we highlight the virus-host interactions that are critical in the context of stroke, including direct effects of acute and persistent viral infections on vascular function, inflammation, and thrombosis. Additionally, we evaluate the systemic changes that occur during viral infection that can predispose individuals to ischemic stroke, including alterations in blood pressure regulation, coagulation, and lipid metabolism. Our review emphasizes the need to further elucidate precise mechanisms involved in viral infections and stroke risk. Future research will inform the development of targeted interventions for stroke prevention in the context of viral diseases.
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| http://dx.doi.org/10.1161/JAHA.124.035892 | DOI Listing |
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