AI Article Synopsis
- - Two new compounds, sucurchalasins A and B, were discovered from an endophytic fungus, consisting of a cytochalasan and a macrolide, connected by a thioether bridge.
- - The structures of these compounds were determined using advanced techniques like NMR, LC-MS/MS, and X-ray crystallography.
- - Sucurchalasins A and B showed cytotoxic effects on cancer cells and exhibited antibacterial properties, indicating potential medicinal value.
Article Abstract
Two sulfur-containing heterodimers of a cytochalasan and a macrolide, sucurchalasins A and B ( and ), and four known cytochalasan monomers (-), as well as four known macrolide derivatives (-), were obtained from the endophytic fungus GDGJ-286. Sucurchalasins A and B ( and ) are the first cytochalasan heterodimers formed via a thioether bridge between cytochalasan and curvularin macrolide units. Their structures were elucidated by detailed analysis of NMR, LC-MS/MS, and X-ray crystallography. In bioassays, and exhibited cytotoxic effects on A2780 cells, with IC values of 3.9 and 8.3 μM, respectively. They also showed antibacterial activities against and with MIC values of 3.1 and 6.3 μg/mL, respectively.
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Sucurchalasins A and B, Sulfur-Containing Heterodimers of a Cytochalasan and a Macrolide from the Endophytic Fungus GDGJ-286.
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State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.
Article Synopsis
- - Two new compounds, sucurchalasins A and B, were discovered from an endophytic fungus, consisting of a cytochalasan and a macrolide, connected by a thioether bridge.
- - The structures of these compounds were determined using advanced techniques like NMR, LC-MS/MS, and X-ray crystallography.
- - Sucurchalasins A and B showed cytotoxic effects on cancer cells and exhibited antibacterial properties, indicating potential medicinal value.
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